The association between cardiac autonomic neuropathy and diabetes control

Maryam Vasheghani,1 Farzaneh Sarvghadi,2 Mohammad Reza Beyranvand31Endocrinology & Metabolism Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrinology & Metabolism Department, Endocrine Research Center, Research Institute for Endocr...

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Autores principales:	Vasheghani M, Sarvghadi F, Beyranvand MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Cardiac Autonomic Neuropathy Diabetes Mellitus Glycemic Control Diabetic Neuropathy Diabetic Autonomic Neuropathy Autonomic Neuropathies Hb A1c Electrocardiogram Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/231bfaf5773d4366bfe680c28aa3c4f3
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spelling	oai:doaj.org-article:231bfaf5773d4366bfe680c28aa3c4f32021-12-02T05:50:22ZThe association between cardiac autonomic neuropathy and diabetes control1178-7007https://doaj.org/article/231bfaf5773d4366bfe680c28aa3c4f32019-04-01T00:00:00Zhttps://www.dovepress.com/the-association-between-cardiac-autonomic-neuropathy-and-diabetes-cont-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Maryam Vasheghani,1 Farzaneh Sarvghadi,2 Mohammad Reza Beyranvand31Endocrinology & Metabolism Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrinology & Metabolism Department, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Interventional Cardiology, Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranIntroduction: Cardiac autonomic neuropathy (CAN) is one of major complications of diabetes mellitus (DM) that increases the risk of cardiovascular disorders, abnormal ventricular depolarization with poor prognosis as well as increased mortality and morbidity. Indeed, CAN has close relation with blood glucose level in diabetic patients. We investigated the relation of CAN with diabetes control.Materials and methods: Totally, 115 diabetic patients (mean age 50.87±13.90 years old; 78 females) underwent study. All patients had DM and cardiac sinus rhythm. Nobody had sickness affecting cardiac rhythm and blood pressure. In addition, they did not take drugs that had effect on blood pressure, cardiac rhythm, and QT interval. Forty-six patients had tight and 69 patients had uncontrolled DM according to American Diabetes Association (ADA) criteria. The CAN was assessed based on heart rate variation during physical examination (at rest tachycardia and orthostatic hypotension) and standard Ewing’s tests (deep-breathing and laying-to-standing tests) with bedside continuous ECG recording. The P-value <0.05 is considered significant.Results: Seventy-five patients (65.2%) had CAN. In patients with CAN, 13.9% were symptomatic and 51.3% were asymptomatic. Resting tachycardia and hypotension were found in 5.2%, 8.7% of patients, respectively. Abnormal deep-breathing and laying-to-standing tests were found in 73% and 71.3% of asymptomatic patients, respectively. CAN was more prevalence at uncontrolled DM (67.3% vs 63.7%) but the difference was not significant. The prevalence of CAN had direct association with duration of DM in both tight and uncontrolled groups (P<0.05). The mean of age, sex, and type of treatment had no association with CAN prevalence.Conclusion: The prevalence of CAN, especially asymptomatic type, was high. Its prevalence was increased with prolonged duration of DM. But we did not find any relationship between CAN and glycemic control level.Keywords: cardiac autonomic neuropathy, diabetes mellitus, glycemic control, diabetic autonomic neuropathy, Hb A1c, electrocardiogramVasheghani MSarvghadi FBeyranvand MRDove Medical PressarticleCardiac Autonomic NeuropathyDiabetes MellitusGlycemic ControlDiabetic NeuropathyDiabetic Autonomic NeuropathyAutonomic NeuropathiesHb A1cElectrocardiogramSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 581-587 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiac Autonomic Neuropathy Diabetes Mellitus Glycemic Control Diabetic Neuropathy Diabetic Autonomic Neuropathy Autonomic Neuropathies Hb A1c Electrocardiogram Specialties of internal medicine RC581-951
spellingShingle	Cardiac Autonomic Neuropathy Diabetes Mellitus Glycemic Control Diabetic Neuropathy Diabetic Autonomic Neuropathy Autonomic Neuropathies Hb A1c Electrocardiogram Specialties of internal medicine RC581-951 Vasheghani M Sarvghadi F Beyranvand MR The association between cardiac autonomic neuropathy and diabetes control
description	Maryam Vasheghani,1 Farzaneh Sarvghadi,2 Mohammad Reza Beyranvand31Endocrinology & Metabolism Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrinology & Metabolism Department, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Interventional Cardiology, Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranIntroduction: Cardiac autonomic neuropathy (CAN) is one of major complications of diabetes mellitus (DM) that increases the risk of cardiovascular disorders, abnormal ventricular depolarization with poor prognosis as well as increased mortality and morbidity. Indeed, CAN has close relation with blood glucose level in diabetic patients. We investigated the relation of CAN with diabetes control.Materials and methods: Totally, 115 diabetic patients (mean age 50.87±13.90 years old; 78 females) underwent study. All patients had DM and cardiac sinus rhythm. Nobody had sickness affecting cardiac rhythm and blood pressure. In addition, they did not take drugs that had effect on blood pressure, cardiac rhythm, and QT interval. Forty-six patients had tight and 69 patients had uncontrolled DM according to American Diabetes Association (ADA) criteria. The CAN was assessed based on heart rate variation during physical examination (at rest tachycardia and orthostatic hypotension) and standard Ewing’s tests (deep-breathing and laying-to-standing tests) with bedside continuous ECG recording. The P-value <0.05 is considered significant.Results: Seventy-five patients (65.2%) had CAN. In patients with CAN, 13.9% were symptomatic and 51.3% were asymptomatic. Resting tachycardia and hypotension were found in 5.2%, 8.7% of patients, respectively. Abnormal deep-breathing and laying-to-standing tests were found in 73% and 71.3% of asymptomatic patients, respectively. CAN was more prevalence at uncontrolled DM (67.3% vs 63.7%) but the difference was not significant. The prevalence of CAN had direct association with duration of DM in both tight and uncontrolled groups (P<0.05). The mean of age, sex, and type of treatment had no association with CAN prevalence.Conclusion: The prevalence of CAN, especially asymptomatic type, was high. Its prevalence was increased with prolonged duration of DM. But we did not find any relationship between CAN and glycemic control level.Keywords: cardiac autonomic neuropathy, diabetes mellitus, glycemic control, diabetic autonomic neuropathy, Hb A1c, electrocardiogram
format	article
author	Vasheghani M Sarvghadi F Beyranvand MR
author_facet	Vasheghani M Sarvghadi F Beyranvand MR
author_sort	Vasheghani M
title	The association between cardiac autonomic neuropathy and diabetes control
title_short	The association between cardiac autonomic neuropathy and diabetes control
title_full	The association between cardiac autonomic neuropathy and diabetes control
title_fullStr	The association between cardiac autonomic neuropathy and diabetes control
title_full_unstemmed	The association between cardiac autonomic neuropathy and diabetes control
title_sort	association between cardiac autonomic neuropathy and diabetes control
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/231bfaf5773d4366bfe680c28aa3c4f3
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The association between cardiac autonomic neuropathy and diabetes control

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