Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling

Plastic reweighting of parallel fiber synaptic strength is a mechanism for the acquisition of cerebellum-dependent motor learning. Here, the authors found that optogenetic activation of PCs generates dendritic Ca2+ signals that induce plasticity in vitro and instruct learned changes to coincident ey...

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Autores principales:	Audrey Bonnan, Matthew M. J. Rowan, Christopher A. Baker, M. McLean Bolton, Jason M. Christie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/231e3ecfe8014b23afce4d2cc0b1ebd2
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spelling	oai:doaj.org-article:231e3ecfe8014b23afce4d2cc0b1ebd22021-12-02T14:30:28ZAutonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling10.1038/s41467-021-22405-82041-1723https://doaj.org/article/231e3ecfe8014b23afce4d2cc0b1ebd22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22405-8https://doaj.org/toc/2041-1723Plastic reweighting of parallel fiber synaptic strength is a mechanism for the acquisition of cerebellum-dependent motor learning. Here, the authors found that optogenetic activation of PCs generates dendritic Ca2+ signals that induce plasticity in vitro and instruct learned changes to coincident eye movements in vivo.Audrey BonnanMatthew M. J. RowanChristopher A. BakerM. McLean BoltonJason M. ChristieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Audrey Bonnan Matthew M. J. Rowan Christopher A. Baker M. McLean Bolton Jason M. Christie Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
description	Plastic reweighting of parallel fiber synaptic strength is a mechanism for the acquisition of cerebellum-dependent motor learning. Here, the authors found that optogenetic activation of PCs generates dendritic Ca2+ signals that induce plasticity in vitro and instruct learned changes to coincident eye movements in vivo.
format	article
author	Audrey Bonnan Matthew M. J. Rowan Christopher A. Baker M. McLean Bolton Jason M. Christie
author_facet	Audrey Bonnan Matthew M. J. Rowan Christopher A. Baker M. McLean Bolton Jason M. Christie
author_sort	Audrey Bonnan
title	Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
title_short	Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
title_full	Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
title_fullStr	Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
title_full_unstemmed	Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
title_sort	autonomous purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/231e3ecfe8014b23afce4d2cc0b1ebd2
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Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling

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