Association between positive history of essential tremor and disease progression in patients with Parkinson's disease

Abstract This study aimed to explore the effect of pre-existing essential tremor (ET) history on the disease progression of Parkinson’s disease (PD). We recruited and followed-up a group of PD patients from March 2009 to July 2020. The ET history of each patient was obtained by retrospective intervi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Zheng Jiang, Wei Song, Bei Cao, Huifang Shang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/231e64c597864c37976f37275ff0755d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:231e64c597864c37976f37275ff0755d
record_format	dspace
spelling	oai:doaj.org-article:231e64c597864c37976f37275ff0755d2021-12-02T11:43:51ZAssociation between positive history of essential tremor and disease progression in patients with Parkinson's disease10.1038/s41598-020-78794-12045-2322https://doaj.org/article/231e64c597864c37976f37275ff0755d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78794-1https://doaj.org/toc/2045-2322Abstract This study aimed to explore the effect of pre-existing essential tremor (ET) history on the disease progression of Parkinson’s disease (PD). We recruited and followed-up a group of PD patients from March 2009 to July 2020. The ET history of each patient was obtained by retrospective interviews or past medical records. Cox proportional hazards models with inverse probability of treatment weighting (IPTW) were used to estimate the hazard ratio (HR) with 95% confidence intervals (CIs). Of 785 patients who completed the followed-up visits, 61 patients (7.8%) reported a history of pre-existing ET. Cox regression models after IPTW indicated that the positive ET history in patients with PD was protective against time to United PD Rating Scale III 14-point increase (HR = 0.301, 95% CI = 0.134–0.678, P = 0.004), time to akinesia and rigidity 8-point increase (HR = 0.417, 95% CI = 0.218–0.796, P = 0.008), time to conversion to Hoehn and Yahr stage 3 (HR = 0.356, 95% CI = 0.131–0.969, P = 0.043), time to develop dyskinesia (HR = 0.160, 95% CI = 0.037–0.698, P = 0.015), and time to Montreal Cognitive Assessment 3-point decrease (HR = 0.389, 95% CI = 0.160–0.946, P = 0.037), but had no relationship with time to tremor 4-point increase (HR = 1.638, 95% CI = 0.822–3.266, P = 0.161) and time to death (HR = 0.713, 95% CI = 0.219–2.319, P = 0.574). Our study indicated that ET history in patients with PD is associated with a benign prognosis with slower motor and non-motor progression.Ruwei OuQianqian WeiYanbing HouLingyu ZhangKuncheng LiuJunyu LinZheng JiangWei SongBei CaoHuifang ShangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruwei Ou Qianqian Wei Yanbing Hou Lingyu Zhang Kuncheng Liu Junyu Lin Zheng Jiang Wei Song Bei Cao Huifang Shang Association between positive history of essential tremor and disease progression in patients with Parkinson's disease
description	Abstract This study aimed to explore the effect of pre-existing essential tremor (ET) history on the disease progression of Parkinson’s disease (PD). We recruited and followed-up a group of PD patients from March 2009 to July 2020. The ET history of each patient was obtained by retrospective interviews or past medical records. Cox proportional hazards models with inverse probability of treatment weighting (IPTW) were used to estimate the hazard ratio (HR) with 95% confidence intervals (CIs). Of 785 patients who completed the followed-up visits, 61 patients (7.8%) reported a history of pre-existing ET. Cox regression models after IPTW indicated that the positive ET history in patients with PD was protective against time to United PD Rating Scale III 14-point increase (HR = 0.301, 95% CI = 0.134–0.678, P = 0.004), time to akinesia and rigidity 8-point increase (HR = 0.417, 95% CI = 0.218–0.796, P = 0.008), time to conversion to Hoehn and Yahr stage 3 (HR = 0.356, 95% CI = 0.131–0.969, P = 0.043), time to develop dyskinesia (HR = 0.160, 95% CI = 0.037–0.698, P = 0.015), and time to Montreal Cognitive Assessment 3-point decrease (HR = 0.389, 95% CI = 0.160–0.946, P = 0.037), but had no relationship with time to tremor 4-point increase (HR = 1.638, 95% CI = 0.822–3.266, P = 0.161) and time to death (HR = 0.713, 95% CI = 0.219–2.319, P = 0.574). Our study indicated that ET history in patients with PD is associated with a benign prognosis with slower motor and non-motor progression.
format	article
author	Ruwei Ou Qianqian Wei Yanbing Hou Lingyu Zhang Kuncheng Liu Junyu Lin Zheng Jiang Wei Song Bei Cao Huifang Shang
author_facet	Ruwei Ou Qianqian Wei Yanbing Hou Lingyu Zhang Kuncheng Liu Junyu Lin Zheng Jiang Wei Song Bei Cao Huifang Shang
author_sort	Ruwei Ou
title	Association between positive history of essential tremor and disease progression in patients with Parkinson's disease
title_short	Association between positive history of essential tremor and disease progression in patients with Parkinson's disease
title_full	Association between positive history of essential tremor and disease progression in patients with Parkinson's disease
title_fullStr	Association between positive history of essential tremor and disease progression in patients with Parkinson's disease
title_full_unstemmed	Association between positive history of essential tremor and disease progression in patients with Parkinson's disease
title_sort	association between positive history of essential tremor and disease progression in patients with parkinson's disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/231e64c597864c37976f37275ff0755d
work_keys_str_mv	AT ruweiou associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT qianqianwei associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT yanbinghou associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT lingyuzhang associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT kunchengliu associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT junyulin associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT zhengjiang associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT weisong associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT beicao associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease AT huifangshang associationbetweenpositivehistoryofessentialtremoranddiseaseprogressioninpatientswithparkinsonsdisease
_version_	1718395330262728704

Association between positive history of essential tremor and disease progression in patients with Parkinson's disease

Ejemplares similares