Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway

Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway

Abstract Transient receptor potential vanilloid 4 (TRPV4) plays an important role in chondrocytes via Ca2+ signaling. However, its role in the progression of osteoarthritis is unclear. This study aimed to evaluate the effects of TRPV4 activation on articular cartilage and chondrocytes stimulated wit...

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Autores principales: Kyosuke Hattori, Nobunori Takahashi, Kenya Terabe, Yoshifumi Ohashi, Kenji Kishimoto, Yutaka Yokota, Mochihito Suzuki, Toshihisa Kojima, Shiro Imagama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/231ecfd498d84543b2e0b82fc0db45a9
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