Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort

Abstract There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child’s predisposition to develop disease later in life. The aim of this study...

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Autores principales:	Maria Tsamou, Dries S. Martens, Ellen Winckelmans, Narjes Madhloum, Bianca Cox, Wilfried Gyselaers, Tim S. Nawrot, Karen Vrijens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2325c4dd638f483b9628a375f9dfbdb0
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spelling	oai:doaj.org-article:2325c4dd638f483b9628a375f9dfbdb02021-12-02T11:40:21ZMother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort10.1038/s41598-017-04026-82045-2322https://doaj.org/article/2325c4dd638f483b9628a375f9dfbdb02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04026-8https://doaj.org/toc/2045-2322Abstract There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child’s predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity. Multiple linear regression models were used to address the associations between pre-pregnancy BMI and placental candidate miRNA expression. Maternal pre-pregnancy BMI averaged (±SD) 23.9 (±4.1) kg/m2. In newborn girls (not in boys) placental miR-20a, miR-34a and miR-222 expression was lower with higher maternal pre-pregnancy BMI. In addition, the association between maternal pre-pregnancy BMI and placental expression of these miRNAs in girls was modified by gestational weight gain. The lower expression of these miRNAs in placenta in association with pre-pregnancy BMI, was only evident in mothers with low weight gain (<14 kg). The placental expression of miR-20a, miR-34a, miR-146a, miR-210 and miR-222 may provide a sex-specific basis for epigenetic effects of pre-pregnancy BMI.Maria TsamouDries S. MartensEllen WinckelmansNarjes MadhloumBianca CoxWilfried GyselaersTim S. NawrotKaren VrijensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Tsamou Dries S. Martens Ellen Winckelmans Narjes Madhloum Bianca Cox Wilfried Gyselaers Tim S. Nawrot Karen Vrijens Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort
description	Abstract There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child’s predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity. Multiple linear regression models were used to address the associations between pre-pregnancy BMI and placental candidate miRNA expression. Maternal pre-pregnancy BMI averaged (±SD) 23.9 (±4.1) kg/m2. In newborn girls (not in boys) placental miR-20a, miR-34a and miR-222 expression was lower with higher maternal pre-pregnancy BMI. In addition, the association between maternal pre-pregnancy BMI and placental expression of these miRNAs in girls was modified by gestational weight gain. The lower expression of these miRNAs in placenta in association with pre-pregnancy BMI, was only evident in mothers with low weight gain (<14 kg). The placental expression of miR-20a, miR-34a, miR-146a, miR-210 and miR-222 may provide a sex-specific basis for epigenetic effects of pre-pregnancy BMI.
format	article
author	Maria Tsamou Dries S. Martens Ellen Winckelmans Narjes Madhloum Bianca Cox Wilfried Gyselaers Tim S. Nawrot Karen Vrijens
author_facet	Maria Tsamou Dries S. Martens Ellen Winckelmans Narjes Madhloum Bianca Cox Wilfried Gyselaers Tim S. Nawrot Karen Vrijens
author_sort	Maria Tsamou
title	Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort
title_short	Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort
title_full	Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort
title_fullStr	Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort
title_full_unstemmed	Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort
title_sort	mother’s pre-pregnancy bmi and placental candidate mirnas: findings from the environage birth cohort
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2325c4dd638f483b9628a375f9dfbdb0
work_keys_str_mv	AT mariatsamou mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT driessmartens mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT ellenwinckelmans mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT narjesmadhloum mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT biancacox mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT wilfriedgyselaers mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT timsnawrot mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort AT karenvrijens mothersprepregnancybmiandplacentalcandidatemirnasfindingsfromtheenvironagebirthcohort
_version_	1718395630071578624

Mother’s Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort

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