Mad1 destabilizes p53 by preventing PML from sequestering MDM2

Mad1 destabilizes p53 by preventing PML from sequestering MDM2

Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex.

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Autores principales: Jun Wan, Samuel Block, Christina M. Scribano, Rebecca Thiry, Karla Esbona, Anjon Audhya, Beth A. Weaver
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/2325e2e3c5334028a09c465010f83a6c
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spelling oai:doaj.org-article:2325e2e3c5334028a09c465010f83a6c2021-12-02T16:57:46ZMad1 destabilizes p53 by preventing PML from sequestering MDM210.1038/s41467-019-09471-92041-1723https://doaj.org/article/2325e2e3c5334028a09c465010f83a6c2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09471-9https://doaj.org/toc/2041-1723Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex.Jun WanSamuel BlockChristina M. ScribanoRebecca ThiryKarla EsbonaAnjon AudhyaBeth A. WeaverNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Wan
Samuel Block
Christina M. Scribano
Rebecca Thiry
Karla Esbona
Anjon Audhya
Beth A. Weaver
Mad1 destabilizes p53 by preventing PML from sequestering MDM2
description Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex.
format article
author Jun Wan
Samuel Block
Christina M. Scribano
Rebecca Thiry
Karla Esbona
Anjon Audhya
Beth A. Weaver
author_facet Jun Wan
Samuel Block
Christina M. Scribano
Rebecca Thiry
Karla Esbona
Anjon Audhya
Beth A. Weaver
author_sort Jun Wan
title Mad1 destabilizes p53 by preventing PML from sequestering MDM2
title_short Mad1 destabilizes p53 by preventing PML from sequestering MDM2
title_full Mad1 destabilizes p53 by preventing PML from sequestering MDM2
title_fullStr Mad1 destabilizes p53 by preventing PML from sequestering MDM2
title_full_unstemmed Mad1 destabilizes p53 by preventing PML from sequestering MDM2
title_sort mad1 destabilizes p53 by preventing pml from sequestering mdm2
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2325e2e3c5334028a09c465010f83a6c
work_keys_str_mv AT junwan mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
AT samuelblock mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
AT christinamscribano mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
AT rebeccathiry mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
AT karlaesbona mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
AT anjonaudhya mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
AT bethaweaver mad1destabilizesp53bypreventingpmlfromsequesteringmdm2
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