Mad1 destabilizes p53 by preventing PML from sequestering MDM2
Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex.
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2325e2e3c5334028a09c465010f83a6c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|