Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice

Abstract The first night effect (FNE) is a type of sleep disturbance caused by an unfamiliar environment, which leads to difficulty falling asleep and reduced sleep duration. Previously, we reported that Lactobacillus fermentum PS150 (PS150) improves sleep conditions in a pentobarbital-induced sleep...

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Autores principales:	Alexander Lin, Ching-Ting Shih, Hsu-Feng Chu, Chieh-Wen Chen, Yu-Ting Cheng, Chien-Chen Wu, Cheryl C. H. Yang, Ying-Chieh Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/232db8673c8f49f4b5299325e4d1142f
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spelling	oai:doaj.org-article:232db8673c8f49f4b5299325e4d1142f2021-12-02T15:08:11ZLactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice10.1038/s41598-021-95659-32045-2322https://doaj.org/article/232db8673c8f49f4b5299325e4d1142f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95659-3https://doaj.org/toc/2045-2322Abstract The first night effect (FNE) is a type of sleep disturbance caused by an unfamiliar environment, which leads to difficulty falling asleep and reduced sleep duration. Previously, we reported that Lactobacillus fermentum PS150 (PS150) improves sleep conditions in a pentobarbital-induced sleep mouse model. In this study, we aimed to evaluate the effect of PS150 on the FNE in mice. Briefly, mice were implanted with electrodes and orally administered PS150 for four weeks, and then the FNE was induced by cage changing. Analysis of polysomnographic signals revealed that intervention with PS150 restored non-rapid eye movement (NREM) sleep length under the FNE. Compared to diphenhydramine, a commonly used sleep aid, PS150 had no unwanted side effects, such as rapid eye movement (REM) sleep deprivation and fragmented sleep. Moreover, temporal analysis revealed that PS150 efficiently reduced both sleep latency and time spent restoring normal levels of REM sleep. Taken together, these results suggest that PS150 efficiently ameliorates sleep disturbance caused by the FNE. Additionally, V3–V4 16S rRNA sequencing revealed significant increases in Erysipelotrichia, Actinobacteria, and Coriobacteriia in fecal specimens of the PS150-treated group, indicating that PS150 induces gut microbiota remodeling.Alexander LinChing-Ting ShihHsu-Feng ChuChieh-Wen ChenYu-Ting ChengChien-Chen WuCheryl C. H. YangYing-Chieh TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Lin Ching-Ting Shih Hsu-Feng Chu Chieh-Wen Chen Yu-Ting Cheng Chien-Chen Wu Cheryl C. H. Yang Ying-Chieh Tsai Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
description	Abstract The first night effect (FNE) is a type of sleep disturbance caused by an unfamiliar environment, which leads to difficulty falling asleep and reduced sleep duration. Previously, we reported that Lactobacillus fermentum PS150 (PS150) improves sleep conditions in a pentobarbital-induced sleep mouse model. In this study, we aimed to evaluate the effect of PS150 on the FNE in mice. Briefly, mice were implanted with electrodes and orally administered PS150 for four weeks, and then the FNE was induced by cage changing. Analysis of polysomnographic signals revealed that intervention with PS150 restored non-rapid eye movement (NREM) sleep length under the FNE. Compared to diphenhydramine, a commonly used sleep aid, PS150 had no unwanted side effects, such as rapid eye movement (REM) sleep deprivation and fragmented sleep. Moreover, temporal analysis revealed that PS150 efficiently reduced both sleep latency and time spent restoring normal levels of REM sleep. Taken together, these results suggest that PS150 efficiently ameliorates sleep disturbance caused by the FNE. Additionally, V3–V4 16S rRNA sequencing revealed significant increases in Erysipelotrichia, Actinobacteria, and Coriobacteriia in fecal specimens of the PS150-treated group, indicating that PS150 induces gut microbiota remodeling.
format	article
author	Alexander Lin Ching-Ting Shih Hsu-Feng Chu Chieh-Wen Chen Yu-Ting Cheng Chien-Chen Wu Cheryl C. H. Yang Ying-Chieh Tsai
author_facet	Alexander Lin Ching-Ting Shih Hsu-Feng Chu Chieh-Wen Chen Yu-Ting Cheng Chien-Chen Wu Cheryl C. H. Yang Ying-Chieh Tsai
author_sort	Alexander Lin
title	Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
title_short	Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
title_full	Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
title_fullStr	Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
title_full_unstemmed	Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
title_sort	lactobacillus fermentum ps150 promotes non-rapid eye movement sleep in the first night effect of mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/232db8673c8f49f4b5299325e4d1142f
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Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice

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