The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols
Abstract The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence t...
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Nature Portfolio
2020
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oai:doaj.org-article:232fc7fb0680416db0848cfad3cc3f0a2021-12-02T17:45:04ZThe presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols10.1038/s41598-020-67151-x2045-2322https://doaj.org/article/232fc7fb0680416db0848cfad3cc3f0a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67151-xhttps://doaj.org/toc/2045-2322Abstract The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach remains modest. To shed more light on this issue, we compared the follicular development between the ovary carrying the dominant follicle or the corpus luteum and the contralateral resting ovary in 90 women who underwent random start controlled ovarian stimulation (COS). In fact, ovarian response did not differ between the two ovaries. Subgroup analyses according to the phase of the cycle at the initiation of COS, the type of malignancy, the use of letrozole and the magnitude of the ovarian response did not allow to identify any condition showing a difference in the follicular response between the active and the resting ovaries. In conclusion, follicular growth does not seem to be perturbed by the presence of a dominant follicle or a corpus luteum.Francesca FilippiEdgardo SomiglianaAndrea BusnelliCristina GuarneriStefania NoliLiliana RestelliPaolo VercelliniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) |
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Medicine R Science Q Francesca Filippi Edgardo Somigliana Andrea Busnelli Cristina Guarneri Stefania Noli Liliana Restelli Paolo Vercellini The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| description |
Abstract The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach remains modest. To shed more light on this issue, we compared the follicular development between the ovary carrying the dominant follicle or the corpus luteum and the contralateral resting ovary in 90 women who underwent random start controlled ovarian stimulation (COS). In fact, ovarian response did not differ between the two ovaries. Subgroup analyses according to the phase of the cycle at the initiation of COS, the type of malignancy, the use of letrozole and the magnitude of the ovarian response did not allow to identify any condition showing a difference in the follicular response between the active and the resting ovaries. In conclusion, follicular growth does not seem to be perturbed by the presence of a dominant follicle or a corpus luteum. |
| format |
article |
| author |
Francesca Filippi Edgardo Somigliana Andrea Busnelli Cristina Guarneri Stefania Noli Liliana Restelli Paolo Vercellini |
| author_facet |
Francesca Filippi Edgardo Somigliana Andrea Busnelli Cristina Guarneri Stefania Noli Liliana Restelli Paolo Vercellini |
| author_sort |
Francesca Filippi |
| title |
The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| title_short |
The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| title_full |
The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| title_fullStr |
The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| title_full_unstemmed |
The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| title_sort |
presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/232fc7fb0680416db0848cfad3cc3f0a |
| work_keys_str_mv |
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| _version_ |
1718379574644965376 |