A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation.
Spore-forming pathogens like Clostridioides difficile depend on germination to initiate infection. During gemination, spores must degrade their cortex layer, which is a thick, protective layer of modified peptidoglycan. Cortex degradation depends on the presence of the spore-specific peptidoglycan m...
Guardado en:
Autores principales: | Carolina Alves Feliciano, Brian E Eckenroth, Oscar R Diaz, Sylvie Doublié, Aimee Shen |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/2331f6a4fdfe4f99b4a48a7423afe147 |
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