Numerical study of shear-based hemolysis in aorta with left ventricular assistance device

Ventricular assistance devices (VADs) for heart failure treatment have been paid high attention among researchers for decades. However, the follow-up complications such as hemolysis and thrombosis require further optimization for this technique. Shear stress has been demonstrated to be significantly...

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Autores principales:	Song Jianfei, Marcel Louis, Specklin Mathieu, Kouidri Smaine
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/23328ac11a404aef878e81ff84828aeb
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spelling	oai:doaj.org-article:23328ac11a404aef878e81ff84828aeb2021-11-12T11:44:34ZNumerical study of shear-based hemolysis in aorta with left ventricular assistance device2267-124210.1051/e3sconf/202132103009https://doaj.org/article/23328ac11a404aef878e81ff84828aeb2021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/97/e3sconf_icchmt2021_03009.pdfhttps://doaj.org/toc/2267-1242Ventricular assistance devices (VADs) for heart failure treatment have been paid high attention among researchers for decades. However, the follow-up complications such as hemolysis and thrombosis require further optimization for this technique. Shear stress has been demonstrated to be significantly related to the hemolysis because of the rupture of red blood cells membrane with a leaking of hemoglobin in the plasma. This issue has already been investigated inside the pump of VAD, but estimations are still lacking regarding hemolysis generation in the aorta itself after VAD implantaion. Thus, the present study aims to evaluate the hemolysis in aorta through establishing the 3D numerical model of aorta with left ventricular assistance device (LVAD). Non-Newtonian Carreau model has been adopted. Comparisons of hemolysis evaluation have been made with two different mathematical models existing in literature. Moreover, the flow topology and hemodynamic variations have been studied. Different working conditions of LVAD have been considered corresponding to different heart failure severities. The results reveal a relatively low level of hemolysis risks in aorta. The thrombosis is more prone to occur in the case of severe heart failure condition.Song JianfeiMarcel LouisSpecklin MathieuKouidri SmaineEDP SciencesarticleEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 321, p 03009 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Environmental sciences GE1-350
spellingShingle	Environmental sciences GE1-350 Song Jianfei Marcel Louis Specklin Mathieu Kouidri Smaine Numerical study of shear-based hemolysis in aorta with left ventricular assistance device
description	Ventricular assistance devices (VADs) for heart failure treatment have been paid high attention among researchers for decades. However, the follow-up complications such as hemolysis and thrombosis require further optimization for this technique. Shear stress has been demonstrated to be significantly related to the hemolysis because of the rupture of red blood cells membrane with a leaking of hemoglobin in the plasma. This issue has already been investigated inside the pump of VAD, but estimations are still lacking regarding hemolysis generation in the aorta itself after VAD implantaion. Thus, the present study aims to evaluate the hemolysis in aorta through establishing the 3D numerical model of aorta with left ventricular assistance device (LVAD). Non-Newtonian Carreau model has been adopted. Comparisons of hemolysis evaluation have been made with two different mathematical models existing in literature. Moreover, the flow topology and hemodynamic variations have been studied. Different working conditions of LVAD have been considered corresponding to different heart failure severities. The results reveal a relatively low level of hemolysis risks in aorta. The thrombosis is more prone to occur in the case of severe heart failure condition.
format	article
author	Song Jianfei Marcel Louis Specklin Mathieu Kouidri Smaine
author_facet	Song Jianfei Marcel Louis Specklin Mathieu Kouidri Smaine
author_sort	Song Jianfei
title	Numerical study of shear-based hemolysis in aorta with left ventricular assistance device
title_short	Numerical study of shear-based hemolysis in aorta with left ventricular assistance device
title_full	Numerical study of shear-based hemolysis in aorta with left ventricular assistance device
title_fullStr	Numerical study of shear-based hemolysis in aorta with left ventricular assistance device
title_full_unstemmed	Numerical study of shear-based hemolysis in aorta with left ventricular assistance device
title_sort	numerical study of shear-based hemolysis in aorta with left ventricular assistance device
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/23328ac11a404aef878e81ff84828aeb
work_keys_str_mv	AT songjianfei numericalstudyofshearbasedhemolysisinaortawithleftventricularassistancedevice AT marcellouis numericalstudyofshearbasedhemolysisinaortawithleftventricularassistancedevice AT specklinmathieu numericalstudyofshearbasedhemolysisinaortawithleftventricularassistancedevice AT kouidrismaine numericalstudyofshearbasedhemolysisinaortawithleftventricularassistancedevice
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Numerical study of shear-based hemolysis in aorta with left ventricular assistance device

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