Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol

Abstract Previous studies have demonstrated that alcohol consumption impairs neuroplasticity in the motor cortex. However, it is unknown whether alcohol produces a similar impairment of neuroplasticity in the dorsolateral prefrontal cortex (DLPFC), a brain region that plays an important role in cogn...

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Autores principales:	Genane Loheswaran, Mera S. Barr, Reza Zomorrodi, Tarek K. Rajji, Daniel M. Blumberger, Bernard Le Foll, Zafiris J. Daskalakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/233387d4ec6343b58c6c92cbe8329403
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spelling	oai:doaj.org-article:233387d4ec6343b58c6c92cbe83294032021-12-02T15:05:01ZImpairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol10.1038/s41598-017-04764-92045-2322https://doaj.org/article/233387d4ec6343b58c6c92cbe83294032017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04764-9https://doaj.org/toc/2045-2322Abstract Previous studies have demonstrated that alcohol consumption impairs neuroplasticity in the motor cortex. However, it is unknown whether alcohol produces a similar impairment of neuroplasticity in the dorsolateral prefrontal cortex (DLPFC), a brain region that plays an important role in cognitive functioning. The aim of the current study was to evaluate the effect of alcohol intoxication on neuroplasticity in the DLPFC. Paired associative stimulation (PAS) combined with electroencephalography (EEG) was used for the induction and measurement of associative LTP-like neuroplasticity in the DLPFC. Fifteen healthy subjects were administered PAS to the DLPFC following consumption of an alcohol (1.5 g/l of body water) or placebo beverage in a within-subject cross-over design. PAS induced neuroplasticity was indexed up to 60 minutes following PAS. Additionally, the effect of alcohol on PAS-induced potentiation of theta-gamma coupling (an index associated with learning and memory) was examined prior to and following PAS. Alcohol consumption resulted in a significant impairment of mean (t = 2.456, df = 13, p = 0.029) and maximum potentiation (t = −2.945, df = 13, p = 0.011) compared to the placebo beverage in the DLPFC and globally. Alcohol also suppressed the potentiation of theta-gamma coupling by PAS. Findings from the present study provide a potential neurophysiological mechanism for impairment of cognitive functioning by alcohol.Genane LoheswaranMera S. BarrReza ZomorrodiTarek K. RajjiDaniel M. BlumbergerBernard Le FollZafiris J. DaskalakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Genane Loheswaran Mera S. Barr Reza Zomorrodi Tarek K. Rajji Daniel M. Blumberger Bernard Le Foll Zafiris J. Daskalakis Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
description	Abstract Previous studies have demonstrated that alcohol consumption impairs neuroplasticity in the motor cortex. However, it is unknown whether alcohol produces a similar impairment of neuroplasticity in the dorsolateral prefrontal cortex (DLPFC), a brain region that plays an important role in cognitive functioning. The aim of the current study was to evaluate the effect of alcohol intoxication on neuroplasticity in the DLPFC. Paired associative stimulation (PAS) combined with electroencephalography (EEG) was used for the induction and measurement of associative LTP-like neuroplasticity in the DLPFC. Fifteen healthy subjects were administered PAS to the DLPFC following consumption of an alcohol (1.5 g/l of body water) or placebo beverage in a within-subject cross-over design. PAS induced neuroplasticity was indexed up to 60 minutes following PAS. Additionally, the effect of alcohol on PAS-induced potentiation of theta-gamma coupling (an index associated with learning and memory) was examined prior to and following PAS. Alcohol consumption resulted in a significant impairment of mean (t = 2.456, df = 13, p = 0.029) and maximum potentiation (t = −2.945, df = 13, p = 0.011) compared to the placebo beverage in the DLPFC and globally. Alcohol also suppressed the potentiation of theta-gamma coupling by PAS. Findings from the present study provide a potential neurophysiological mechanism for impairment of cognitive functioning by alcohol.
format	article
author	Genane Loheswaran Mera S. Barr Reza Zomorrodi Tarek K. Rajji Daniel M. Blumberger Bernard Le Foll Zafiris J. Daskalakis
author_facet	Genane Loheswaran Mera S. Barr Reza Zomorrodi Tarek K. Rajji Daniel M. Blumberger Bernard Le Foll Zafiris J. Daskalakis
author_sort	Genane Loheswaran
title	Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
title_short	Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
title_full	Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
title_fullStr	Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
title_full_unstemmed	Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
title_sort	impairment of neuroplasticity in the dorsolateral prefrontal cortex by alcohol
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/233387d4ec6343b58c6c92cbe8329403
work_keys_str_mv	AT genaneloheswaran impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol AT merasbarr impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol AT rezazomorrodi impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol AT tarekkrajji impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol AT danielmblumberger impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol AT bernardlefoll impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol AT zafirisjdaskalakis impairmentofneuroplasticityinthedorsolateralprefrontalcortexbyalcohol
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Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol

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