CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment

Sequential generation of layer-specific cortical neurons requires radial glial cells (RGCs) to balance self-renewal and commitment. Here the authors show that RGCs and lineage committed progenitors are defined by distinct cell cycle phases and CYCLIN-B1/2 cooperates with CDK1 to activate Notch and m...

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Autores principales:	Daniel W. Hagey, Danijal Topcic, Nigel Kee, Florie Reynaud, Maria Bergsland, Thomas Perlmann, Jonas Muhr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/233448a846a14b9a858b7a56acc46218
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spelling	oai:doaj.org-article:233448a846a14b9a858b7a56acc462182021-12-02T17:52:09ZCYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment10.1038/s41467-020-16597-82041-1723https://doaj.org/article/233448a846a14b9a858b7a56acc462182020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16597-8https://doaj.org/toc/2041-1723Sequential generation of layer-specific cortical neurons requires radial glial cells (RGCs) to balance self-renewal and commitment. Here the authors show that RGCs and lineage committed progenitors are defined by distinct cell cycle phases and CYCLIN-B1/2 cooperates with CDK1 to activate Notch and maintain RGCs.Daniel W. HageyDanijal TopcicNigel KeeFlorie ReynaudMaria BergslandThomas PerlmannJonas MuhrNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel W. Hagey Danijal Topcic Nigel Kee Florie Reynaud Maria Bergsland Thomas Perlmann Jonas Muhr CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
description	Sequential generation of layer-specific cortical neurons requires radial glial cells (RGCs) to balance self-renewal and commitment. Here the authors show that RGCs and lineage committed progenitors are defined by distinct cell cycle phases and CYCLIN-B1/2 cooperates with CDK1 to activate Notch and maintain RGCs.
format	article
author	Daniel W. Hagey Danijal Topcic Nigel Kee Florie Reynaud Maria Bergsland Thomas Perlmann Jonas Muhr
author_facet	Daniel W. Hagey Danijal Topcic Nigel Kee Florie Reynaud Maria Bergsland Thomas Perlmann Jonas Muhr
author_sort	Daniel W. Hagey
title	CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
title_short	CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
title_full	CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
title_fullStr	CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
title_full_unstemmed	CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
title_sort	cyclin-b1/2 and -d1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/233448a846a14b9a858b7a56acc46218
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CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment

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