IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin

Epidermal intraepithelial lymphocytes (IEL) produce IL-13, but the physiological role of this cytokine production is not clear. Here the authors show that IEL-production of IL-13 is a vital lymphoid stress surveillance mechanism driving crosstalk with epithelial cells to maintain tissue homeostasis...

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Autores principales:	Tim Dalessandri, Greg Crawford, Mark Hayes, Rocio Castro Seoane, Jessica Strid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2335273dce5f444c94c9bd1335d4930d
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spelling	oai:doaj.org-article:2335273dce5f444c94c9bd1335d4930d2021-12-02T15:34:56ZIL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin10.1038/ncomms120802041-1723https://doaj.org/article/2335273dce5f444c94c9bd1335d4930d2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12080https://doaj.org/toc/2041-1723Epidermal intraepithelial lymphocytes (IEL) produce IL-13, but the physiological role of this cytokine production is not clear. Here the authors show that IEL-production of IL-13 is a vital lymphoid stress surveillance mechanism driving crosstalk with epithelial cells to maintain tissue homeostasis and inhibit chemical carcinogenesis in mice.Tim DalessandriGreg CrawfordMark HayesRocio Castro SeoaneJessica StridNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tim Dalessandri Greg Crawford Mark Hayes Rocio Castro Seoane Jessica Strid IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
description	Epidermal intraepithelial lymphocytes (IEL) produce IL-13, but the physiological role of this cytokine production is not clear. Here the authors show that IEL-production of IL-13 is a vital lymphoid stress surveillance mechanism driving crosstalk with epithelial cells to maintain tissue homeostasis and inhibit chemical carcinogenesis in mice.
format	article
author	Tim Dalessandri Greg Crawford Mark Hayes Rocio Castro Seoane Jessica Strid
author_facet	Tim Dalessandri Greg Crawford Mark Hayes Rocio Castro Seoane Jessica Strid
author_sort	Tim Dalessandri
title	IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
title_short	IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
title_full	IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
title_fullStr	IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
title_full_unstemmed	IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
title_sort	il-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2335273dce5f444c94c9bd1335d4930d
work_keys_str_mv	AT timdalessandri il13fromintraepitheliallymphocytesregulatestissuehomeostasisandprotectsagainstcarcinogenesisintheskin AT gregcrawford il13fromintraepitheliallymphocytesregulatestissuehomeostasisandprotectsagainstcarcinogenesisintheskin AT markhayes il13fromintraepitheliallymphocytesregulatestissuehomeostasisandprotectsagainstcarcinogenesisintheskin AT rociocastroseoane il13fromintraepitheliallymphocytesregulatestissuehomeostasisandprotectsagainstcarcinogenesisintheskin AT jessicastrid il13fromintraepitheliallymphocytesregulatestissuehomeostasisandprotectsagainstcarcinogenesisintheskin
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IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin

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