Typing tumors using pathways selected by somatic evolution

Informative pathways driving cancer pathogenesis and subtypes can be difficult to identify in the presence of many gene interactions irrelevant to cancer. Here, the authors describe an approach for cancer gene pathway analysis based on key molecular interactions that drive cancer in relevant tissue...

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Autores principales:	Sheng Wang, Jianzhu Ma, Wei Zhang, John Paul Shen, Justin Huang, Jian Peng, Trey Ideker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23364b3760004de1a37cb9eef7adaa17
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spelling	oai:doaj.org-article:23364b3760004de1a37cb9eef7adaa172021-12-02T14:41:17ZTyping tumors using pathways selected by somatic evolution10.1038/s41467-018-06464-y2041-1723https://doaj.org/article/23364b3760004de1a37cb9eef7adaa172018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06464-yhttps://doaj.org/toc/2041-1723Informative pathways driving cancer pathogenesis and subtypes can be difficult to identify in the presence of many gene interactions irrelevant to cancer. Here, the authors describe an approach for cancer gene pathway analysis based on key molecular interactions that drive cancer in relevant tissue types, and they assemble a focused map of Evolutionarily Selected Pathways (ESP) with interactions supported by both protein–protein binding and genetic epistasis during somatic tumor evolution.Sheng WangJianzhu MaWei ZhangJohn Paul ShenJustin HuangJian PengTrey IdekerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sheng Wang Jianzhu Ma Wei Zhang John Paul Shen Justin Huang Jian Peng Trey Ideker Typing tumors using pathways selected by somatic evolution
description	Informative pathways driving cancer pathogenesis and subtypes can be difficult to identify in the presence of many gene interactions irrelevant to cancer. Here, the authors describe an approach for cancer gene pathway analysis based on key molecular interactions that drive cancer in relevant tissue types, and they assemble a focused map of Evolutionarily Selected Pathways (ESP) with interactions supported by both protein–protein binding and genetic epistasis during somatic tumor evolution.
format	article
author	Sheng Wang Jianzhu Ma Wei Zhang John Paul Shen Justin Huang Jian Peng Trey Ideker
author_facet	Sheng Wang Jianzhu Ma Wei Zhang John Paul Shen Justin Huang Jian Peng Trey Ideker
author_sort	Sheng Wang
title	Typing tumors using pathways selected by somatic evolution
title_short	Typing tumors using pathways selected by somatic evolution
title_full	Typing tumors using pathways selected by somatic evolution
title_fullStr	Typing tumors using pathways selected by somatic evolution
title_full_unstemmed	Typing tumors using pathways selected by somatic evolution
title_sort	typing tumors using pathways selected by somatic evolution
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/23364b3760004de1a37cb9eef7adaa17
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_version_	1718389917868883968

Typing tumors using pathways selected by somatic evolution

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