The Role of Endogenous Metal Nanoparticles in Biological Systems

The blood and tissues of vertebrate animals and mammals contain small endogenous metal nanoparticles. These nanoparticles were observed to be composed of individual atoms of iron, copper, zinc, silver, gold, platinum, and other metals. Metal nanoparticles can bind proteins and produce proteinaceous...

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Autor principal:	Vitaly Vodyanoy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	proteons blood olfaction cancer prions Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2338055b050b40ce9e9073c90fd49eaf
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spelling	oai:doaj.org-article:2338055b050b40ce9e9073c90fd49eaf2021-11-25T16:52:06ZThe Role of Endogenous Metal Nanoparticles in Biological Systems10.3390/biom111115742218-273Xhttps://doaj.org/article/2338055b050b40ce9e9073c90fd49eaf2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1574https://doaj.org/toc/2218-273XThe blood and tissues of vertebrate animals and mammals contain small endogenous metal nanoparticles. These nanoparticles were observed to be composed of individual atoms of iron, copper, zinc, silver, gold, platinum, and other metals. Metal nanoparticles can bind proteins and produce proteinaceous particles called proteons. A small fraction of the entire pool of nanoparticles is usually linked with proteins to form proteons. These endogenous metal nanoparticles, along with engineered zinc and copper nanoparticles at subnanomolar levels, were shown to be lethal to cultured cancer cells. These nanoparticles appear to be elemental crystalline metal nanoparticles. It was discovered that zinc nanoparticles produce no odor response but increase the odor reaction if mixed with an odorant. Some other metal nanoparticles, including copper, silver, gold, and platinum nanoparticles, do not affect the responses to odorants. The sources of metal nanoparticles in animal blood and tissues may include dietary plants and gut microorganisms. The solid physiological and biochemical properties of metal nanoparticles reflect their importance in cell homeostasis and disease.Vitaly VodyanoyMDPI AGarticleproteonsbloodolfactioncancerprionsMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1574, p 1574 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	proteons blood olfaction cancer prions Microbiology QR1-502
spellingShingle	proteons blood olfaction cancer prions Microbiology QR1-502 Vitaly Vodyanoy The Role of Endogenous Metal Nanoparticles in Biological Systems
description	The blood and tissues of vertebrate animals and mammals contain small endogenous metal nanoparticles. These nanoparticles were observed to be composed of individual atoms of iron, copper, zinc, silver, gold, platinum, and other metals. Metal nanoparticles can bind proteins and produce proteinaceous particles called proteons. A small fraction of the entire pool of nanoparticles is usually linked with proteins to form proteons. These endogenous metal nanoparticles, along with engineered zinc and copper nanoparticles at subnanomolar levels, were shown to be lethal to cultured cancer cells. These nanoparticles appear to be elemental crystalline metal nanoparticles. It was discovered that zinc nanoparticles produce no odor response but increase the odor reaction if mixed with an odorant. Some other metal nanoparticles, including copper, silver, gold, and platinum nanoparticles, do not affect the responses to odorants. The sources of metal nanoparticles in animal blood and tissues may include dietary plants and gut microorganisms. The solid physiological and biochemical properties of metal nanoparticles reflect their importance in cell homeostasis and disease.
format	article
author	Vitaly Vodyanoy
author_facet	Vitaly Vodyanoy
author_sort	Vitaly Vodyanoy
title	The Role of Endogenous Metal Nanoparticles in Biological Systems
title_short	The Role of Endogenous Metal Nanoparticles in Biological Systems
title_full	The Role of Endogenous Metal Nanoparticles in Biological Systems
title_fullStr	The Role of Endogenous Metal Nanoparticles in Biological Systems
title_full_unstemmed	The Role of Endogenous Metal Nanoparticles in Biological Systems
title_sort	role of endogenous metal nanoparticles in biological systems
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2338055b050b40ce9e9073c90fd49eaf
work_keys_str_mv	AT vitalyvodyanoy theroleofendogenousmetalnanoparticlesinbiologicalsystems AT vitalyvodyanoy roleofendogenousmetalnanoparticlesinbiologicalsystems
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The Role of Endogenous Metal Nanoparticles in Biological Systems

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