Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury

Acute kidney injury (AKI) is a major contributor to in-hospital morbidity and mortality. Vancomycin, one of the most commonly used antibiotics in a clinical setting, is associated with AKI, with its incidence ranging up to 43%. Despite the high demand, few studies have investigated serum biomarkers...

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Autores principales:	Sang-Mi Kim, Hyun-Seung Lee, Min-Ji Kim, Hyung-Doo Park, Soo-Youn Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vancomycin-induced kidney injury vancomycin nephrotoxicity serum biomarker trefoil factor-3 cystatin C Medicine R
Acceso en línea:	https://doaj.org/article/2338c5dd26f34f3b956c7b5a3e6004df
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spelling	oai:doaj.org-article:2338c5dd26f34f3b956c7b5a3e6004df2021-11-11T17:37:56ZDiagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury10.3390/jcm102150052077-0383https://doaj.org/article/2338c5dd26f34f3b956c7b5a3e6004df2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5005https://doaj.org/toc/2077-0383Acute kidney injury (AKI) is a major contributor to in-hospital morbidity and mortality. Vancomycin, one of the most commonly used antibiotics in a clinical setting, is associated with AKI, with its incidence ranging up to 43%. Despite the high demand, few studies have investigated serum biomarkers to detect vancomycin-induced kidney injury (VIKI). Here, we evaluated the diagnostic value of nine candidate serum biomarkers for VIKI. A total of 23,182 cases referred for vancomycin concentration measurement from January 2018 to December 2019 were screened and 28 subjects with confirmed VIKI were enrolled (VIKI group). Age- and sex- matched control group consisted of 21 subjects who underwent vancomycin therapy without developing VIKI (non-VIKI group), and 23 healthy controls (HC group). The serum concentrations of clusterin, retinol binding protein 4 (RBP4), interleukin-18 (IL-18), tumor necrosis factor receptor 1 (TNF-R1), C-X-C motif chemokine ligand 10 (CXCL10), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin, trefoil factor-3 (TFF3), and cystatin C were compared among the three groups, and their correlations with estimated glomerular filtration rate (eGFR) and diagnostic values for VIKI were assessed. All of the biomarkers except clusterin and RBP4 exhibited significant elevation in the VIKI group. Serum TFF3, cystatin C, TNF-R1, and osteopontin demonstrated an excellent diagnostic value for VIKI (TFF3, area under the curve (AUC) 0.932; cystatin C, AUC 0.917; TNF-R1, AUC 0.866; osteopontin, AUC 0.787); and except osteopontin, a strong negative correlation with eGFR (TFF3, r = −0.71; cystatin C, r = −0.70; TNF-R1, r = −0.60). IL-18, CXCL10, and NGAL showed weak correlation with eGFR and moderate diagnostic value for VIKI. This study tested multiple serum biomarkers for VIKI and showed that serum TFF3, cystatin C, TNF-R1, and osteopontin could efficiently discriminate VIKI patients. Further studies are warranted to clarify the diagnostic value of these biomarkers in VIKI.Sang-Mi KimHyun-Seung LeeMin-Ji KimHyung-Doo ParkSoo-Youn LeeMDPI AGarticlevancomycin-induced kidney injuryvancomycinnephrotoxicityserum biomarkertrefoil factor-3cystatin CMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5005, p 5005 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vancomycin-induced kidney injury vancomycin nephrotoxicity serum biomarker trefoil factor-3 cystatin C Medicine R
spellingShingle	vancomycin-induced kidney injury vancomycin nephrotoxicity serum biomarker trefoil factor-3 cystatin C Medicine R Sang-Mi Kim Hyun-Seung Lee Min-Ji Kim Hyung-Doo Park Soo-Youn Lee Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury
description	Acute kidney injury (AKI) is a major contributor to in-hospital morbidity and mortality. Vancomycin, one of the most commonly used antibiotics in a clinical setting, is associated with AKI, with its incidence ranging up to 43%. Despite the high demand, few studies have investigated serum biomarkers to detect vancomycin-induced kidney injury (VIKI). Here, we evaluated the diagnostic value of nine candidate serum biomarkers for VIKI. A total of 23,182 cases referred for vancomycin concentration measurement from January 2018 to December 2019 were screened and 28 subjects with confirmed VIKI were enrolled (VIKI group). Age- and sex- matched control group consisted of 21 subjects who underwent vancomycin therapy without developing VIKI (non-VIKI group), and 23 healthy controls (HC group). The serum concentrations of clusterin, retinol binding protein 4 (RBP4), interleukin-18 (IL-18), tumor necrosis factor receptor 1 (TNF-R1), C-X-C motif chemokine ligand 10 (CXCL10), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin, trefoil factor-3 (TFF3), and cystatin C were compared among the three groups, and their correlations with estimated glomerular filtration rate (eGFR) and diagnostic values for VIKI were assessed. All of the biomarkers except clusterin and RBP4 exhibited significant elevation in the VIKI group. Serum TFF3, cystatin C, TNF-R1, and osteopontin demonstrated an excellent diagnostic value for VIKI (TFF3, area under the curve (AUC) 0.932; cystatin C, AUC 0.917; TNF-R1, AUC 0.866; osteopontin, AUC 0.787); and except osteopontin, a strong negative correlation with eGFR (TFF3, r = −0.71; cystatin C, r = −0.70; TNF-R1, r = −0.60). IL-18, CXCL10, and NGAL showed weak correlation with eGFR and moderate diagnostic value for VIKI. This study tested multiple serum biomarkers for VIKI and showed that serum TFF3, cystatin C, TNF-R1, and osteopontin could efficiently discriminate VIKI patients. Further studies are warranted to clarify the diagnostic value of these biomarkers in VIKI.
format	article
author	Sang-Mi Kim Hyun-Seung Lee Min-Ji Kim Hyung-Doo Park Soo-Youn Lee
author_facet	Sang-Mi Kim Hyun-Seung Lee Min-Ji Kim Hyung-Doo Park Soo-Youn Lee
author_sort	Sang-Mi Kim
title	Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury
title_short	Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury
title_full	Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury
title_fullStr	Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury
title_full_unstemmed	Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury
title_sort	diagnostic value of multiple serum biomarkers for vancomycin-induced kidney injury
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2338c5dd26f34f3b956c7b5a3e6004df
work_keys_str_mv	AT sangmikim diagnosticvalueofmultipleserumbiomarkersforvancomycininducedkidneyinjury AT hyunseunglee diagnosticvalueofmultipleserumbiomarkersforvancomycininducedkidneyinjury AT minjikim diagnosticvalueofmultipleserumbiomarkersforvancomycininducedkidneyinjury AT hyungdoopark diagnosticvalueofmultipleserumbiomarkersforvancomycininducedkidneyinjury AT sooyounlee diagnosticvalueofmultipleserumbiomarkersforvancomycininducedkidneyinjury
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Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury

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