Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicatin...

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Autores principales:	Ali Seifinejad, Sha Li, Marie-Laure Possovre, Anne Vassalli, Mehdi Tafti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2338f9f632924b529de47dc3761ffb85
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spelling	oai:doaj.org-article:2338f9f632924b529de47dc3761ffb852021-12-02T15:39:19ZHypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy10.1038/s41467-020-19862-y2041-1723https://doaj.org/article/2338f9f632924b529de47dc3761ffb852020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19862-yhttps://doaj.org/toc/2041-1723Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicating that these are two different states but are both regulated by hypocretinergic input to serotonergic neurons.Ali SeifinejadSha LiMarie-Laure PossovreAnne VassalliMehdi TaftiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ali Seifinejad Sha Li Marie-Laure Possovre Anne Vassalli Mehdi Tafti Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
description	Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicating that these are two different states but are both regulated by hypocretinergic input to serotonergic neurons.
format	article
author	Ali Seifinejad Sha Li Marie-Laure Possovre Anne Vassalli Mehdi Tafti
author_facet	Ali Seifinejad Sha Li Marie-Laure Possovre Anne Vassalli Mehdi Tafti
author_sort	Ali Seifinejad
title	Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_short	Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_full	Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_fullStr	Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_full_unstemmed	Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_sort	hypocretinergic interactions with the serotonergic system regulate rem sleep and cataplexy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2338f9f632924b529de47dc3761ffb85
work_keys_str_mv	AT aliseifinejad hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy AT shali hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy AT marielaurepossovre hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy AT annevassalli hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy AT mehditafti hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy
_version_	1718385919444123648

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

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