Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicatin...

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Autores principales: Ali Seifinejad, Sha Li, Marie-Laure Possovre, Anne Vassalli, Mehdi Tafti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2338f9f632924b529de47dc3761ffb85
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