Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

Many organs develop through branching morphogenesis, but whether the underlying mechanisms are shared is unknown. Here, the authors show that a ligand-receptor based Turing mechanisms, similar to that observed in lung development, likely underlies branching morphogenesis of the kidney.

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Autores principales:	Denis Menshykau, Odyssé Michos, Christine Lang, Lisa Conrad, Andrew P. McMahon, Dagmar Iber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23390cc3b377427c9608e740d14e253f
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spelling	oai:doaj.org-article:23390cc3b377427c9608e740d14e253f2021-12-02T17:33:11ZImage-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback10.1038/s41467-018-08212-82041-1723https://doaj.org/article/23390cc3b377427c9608e740d14e253f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08212-8https://doaj.org/toc/2041-1723Many organs develop through branching morphogenesis, but whether the underlying mechanisms are shared is unknown. Here, the authors show that a ligand-receptor based Turing mechanisms, similar to that observed in lung development, likely underlies branching morphogenesis of the kidney.Denis MenshykauOdyssé MichosChristine LangLisa ConradAndrew P. McMahonDagmar IberNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Denis Menshykau Odyssé Michos Christine Lang Lisa Conrad Andrew P. McMahon Dagmar Iber Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
description	Many organs develop through branching morphogenesis, but whether the underlying mechanisms are shared is unknown. Here, the authors show that a ligand-receptor based Turing mechanisms, similar to that observed in lung development, likely underlies branching morphogenesis of the kidney.
format	article
author	Denis Menshykau Odyssé Michos Christine Lang Lisa Conrad Andrew P. McMahon Dagmar Iber
author_facet	Denis Menshykau Odyssé Michos Christine Lang Lisa Conrad Andrew P. McMahon Dagmar Iber
author_sort	Denis Menshykau
title	Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
title_short	Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
title_full	Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
title_fullStr	Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
title_full_unstemmed	Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback
title_sort	image-based modeling of kidney branching morphogenesis reveals gdnf-ret based turing-type mechanism and pattern-modulating wnt11 feedback
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/23390cc3b377427c9608e740d14e253f
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Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

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