Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

Many organs develop through branching morphogenesis, but whether the underlying mechanisms are shared is unknown. Here, the authors show that a ligand-receptor based Turing mechanisms, similar to that observed in lung development, likely underlies branching morphogenesis of the kidney.

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Detalles Bibliográficos
Autores principales: Denis Menshykau, Odyssé Michos, Christine Lang, Lisa Conrad, Andrew P. McMahon, Dagmar Iber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/23390cc3b377427c9608e740d14e253f
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