Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization

Abstract Quantitative susceptibility mapping (QSM) is a novel processing method for gradient-echo magnetic resonance imaging (MRI). Higher magnetic susceptibility in cortical veins have been observed on susceptibility maps in the ischemic hemisphere of stroke patients, indicating an increased oxygen...

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Autores principales:	Jasmin Probst, Marco Rohner, Malin Zahn, Marco Piccirelli, Athina Pangalu, Andreas Luft, Andreas Deistung, Jan Klohs, Susanne Wegener
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23394c3ce1454226b8184af32fb54ff2
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spelling	oai:doaj.org-article:23394c3ce1454226b8184af32fb54ff22021-12-02T14:53:49ZQuantitative susceptibility mapping in ischemic stroke patients after successful recanalization10.1038/s41598-021-95265-32045-2322https://doaj.org/article/23394c3ce1454226b8184af32fb54ff22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95265-3https://doaj.org/toc/2045-2322Abstract Quantitative susceptibility mapping (QSM) is a novel processing method for gradient-echo magnetic resonance imaging (MRI). Higher magnetic susceptibility in cortical veins have been observed on susceptibility maps in the ischemic hemisphere of stroke patients, indicating an increased oxygen extraction fraction (OEF). Our goal was to investigate susceptibility in veins of stroke patients after successful recanalization in order to analyze the value of QSM in predicting tissue prognosis and clinical outcome. We analyzed MR images of 23 patients with stroke due to unilateral middle cerebral artery (MCA)-M1/M2 occlusion acquired 24–72 h after successful thrombectomy. The susceptibilities of veins were obtained from QSM and compared between the stroke territory, the ipsilateral non-ischemic MCA territory and the contralateral MCA territory. As outcome variables, early infarct size and functional disability (modified Rankin Scale, mRS) after 3–5 months was used. The median susceptibility value of cortical veins in the ischemic core was 41% lower compared to the ipsilateral non-ischemic MCA territory and 38% lower than on the contralateral MCA territory. Strikingly, in none of the patients prominent vessels with high susceptibility signal were found after recanalization. Venous susceptibility values within the infarct did not correlate with infarct volume or functional disability after 3–5 months. Low venous susceptibility within the infarct core after successful recanalization of the occluded vessel likely indicates poor oxygen extraction arising from tissue damage. We did not identify peri-infarct tissue with increased susceptibility values as potential surrogate of former penumbral areas. We found no correlation of QSM parameters with infarct size or outcome.Jasmin ProbstMarco RohnerMalin ZahnMarco PiccirelliAthina PangaluAndreas LuftAndreas DeistungJan KlohsSusanne WegenerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jasmin Probst Marco Rohner Malin Zahn Marco Piccirelli Athina Pangalu Andreas Luft Andreas Deistung Jan Klohs Susanne Wegener Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
description	Abstract Quantitative susceptibility mapping (QSM) is a novel processing method for gradient-echo magnetic resonance imaging (MRI). Higher magnetic susceptibility in cortical veins have been observed on susceptibility maps in the ischemic hemisphere of stroke patients, indicating an increased oxygen extraction fraction (OEF). Our goal was to investigate susceptibility in veins of stroke patients after successful recanalization in order to analyze the value of QSM in predicting tissue prognosis and clinical outcome. We analyzed MR images of 23 patients with stroke due to unilateral middle cerebral artery (MCA)-M1/M2 occlusion acquired 24–72 h after successful thrombectomy. The susceptibilities of veins were obtained from QSM and compared between the stroke territory, the ipsilateral non-ischemic MCA territory and the contralateral MCA territory. As outcome variables, early infarct size and functional disability (modified Rankin Scale, mRS) after 3–5 months was used. The median susceptibility value of cortical veins in the ischemic core was 41% lower compared to the ipsilateral non-ischemic MCA territory and 38% lower than on the contralateral MCA territory. Strikingly, in none of the patients prominent vessels with high susceptibility signal were found after recanalization. Venous susceptibility values within the infarct did not correlate with infarct volume or functional disability after 3–5 months. Low venous susceptibility within the infarct core after successful recanalization of the occluded vessel likely indicates poor oxygen extraction arising from tissue damage. We did not identify peri-infarct tissue with increased susceptibility values as potential surrogate of former penumbral areas. We found no correlation of QSM parameters with infarct size or outcome.
format	article
author	Jasmin Probst Marco Rohner Malin Zahn Marco Piccirelli Athina Pangalu Andreas Luft Andreas Deistung Jan Klohs Susanne Wegener
author_facet	Jasmin Probst Marco Rohner Malin Zahn Marco Piccirelli Athina Pangalu Andreas Luft Andreas Deistung Jan Klohs Susanne Wegener
author_sort	Jasmin Probst
title	Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
title_short	Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
title_full	Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
title_fullStr	Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
title_full_unstemmed	Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
title_sort	quantitative susceptibility mapping in ischemic stroke patients after successful recanalization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23394c3ce1454226b8184af32fb54ff2
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Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization

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