Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia

Samuelson et al show that alcohol impairs the production/processing of microbial metabolites, specifically tryptophan catabolites, resulting in immune dysregulation and impaired cellular trafficking for optimal host defense. The metabolite, indole, or probiotics making indole metabolites mitigate al...

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Autores principales:	Derrick R. Samuelson, Min Gu, Judd E. Shellito, Patricia E. Molina, Christopher M. Taylor, Meng Luo, David A. Welsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2339b110998f426186338b148349ae17
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spelling	oai:doaj.org-article:2339b110998f426186338b148349ae172021-12-02T19:02:27ZPulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia10.1038/s42003-021-02524-02399-3642https://doaj.org/article/2339b110998f426186338b148349ae172021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02524-0https://doaj.org/toc/2399-3642Samuelson et al show that alcohol impairs the production/processing of microbial metabolites, specifically tryptophan catabolites, resulting in immune dysregulation and impaired cellular trafficking for optimal host defense. The metabolite, indole, or probiotics making indole metabolites mitigate alcohol-induced susceptibility to Klebsiella-associated pneumonia, and that the mechanisms are partially dependent on AhR.Derrick R. SamuelsonMin GuJudd E. ShellitoPatricia E. MolinaChristopher M. TaylorMeng LuoDavid A. WelshNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Derrick R. Samuelson Min Gu Judd E. Shellito Patricia E. Molina Christopher M. Taylor Meng Luo David A. Welsh Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia
description	Samuelson et al show that alcohol impairs the production/processing of microbial metabolites, specifically tryptophan catabolites, resulting in immune dysregulation and impaired cellular trafficking for optimal host defense. The metabolite, indole, or probiotics making indole metabolites mitigate alcohol-induced susceptibility to Klebsiella-associated pneumonia, and that the mechanisms are partially dependent on AhR.
format	article
author	Derrick R. Samuelson Min Gu Judd E. Shellito Patricia E. Molina Christopher M. Taylor Meng Luo David A. Welsh
author_facet	Derrick R. Samuelson Min Gu Judd E. Shellito Patricia E. Molina Christopher M. Taylor Meng Luo David A. Welsh
author_sort	Derrick R. Samuelson
title	Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia
title_short	Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia
title_full	Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia
title_fullStr	Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia
title_full_unstemmed	Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia
title_sort	pulmonary immune cell trafficking promotes host defense against alcohol-associated klebsiella pneumonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2339b110998f426186338b148349ae17
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Pulmonary immune cell trafficking promotes host defense against alcohol-associated Klebsiella pneumonia

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