Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection

Membranous nephropathy (MN) is currently classified as either primary – often associated with positive anti-phospholipase-A2 receptor (PLA2R) autoantibodies – or as secondary – associated with malignancy, infection, medications, or autoimmune disease. We present a case of biopsy-proven MN with very...

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Autores principales:	Lyle W. Baker, Jaime Jimenez-Lopez, Xochiquetzal J. Geiger, Nabeel Aslam
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	membranous glomerulonephritis anti-phospholipase-a2 receptor antibodies malignancy renal cell carcinoma nephrotic syndrome Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/233a25bf3d4949f692b2b338038fcfc1
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spelling	oai:doaj.org-article:233a25bf3d4949f692b2b338038fcfc12021-12-02T12:40:23ZMalignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection2296-970510.1159/000520399https://doaj.org/article/233a25bf3d4949f692b2b338038fcfc12021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520399https://doaj.org/toc/2296-9705Membranous nephropathy (MN) is currently classified as either primary – often associated with positive anti-phospholipase-A2 receptor (PLA2R) autoantibodies – or as secondary – associated with malignancy, infection, medications, or autoimmune disease. We present a case of biopsy-proven MN with very high serum titer of anti-PLA2R autoantibodies in a patient with a synchronous diagnosis of poorly differentiated esophageal adenocarcinoma and renal cell carcinoma who presented with nephrotic syndrome. Based on the current classification, MN in the presence of active malignancy is diagnosed as secondary and unlikely to have positive anti-PLA2R autoantibodies. This raises several questions: whether this patient has secondary MN associated with malignancy and coincidentally discovered anti-PLA2R autoantibodies, primary MN due to anti-PLA2R autoantibodies with coincidentally discovered malignancy, or whether malignancy can induce the formation of anti-PLA2R autoantibodies that result in MN. This case report highlights the importance of age-appropriate cancer screening, even in patients with presumed primary MN and positive anti-PLA2R autoantibodies.Lyle W. BakerJaime Jimenez-LopezXochiquetzal J. GeigerNabeel AslamKarger Publishersarticlemembranous glomerulonephritisanti-phospholipase-a2 receptor antibodiesmalignancyrenal cell carcinomanephrotic syndromeDiseases of the genitourinary system. UrologyRC870-923ENCase Reports in Nephrology and Dialysis, Vol 11, Iss 3, Pp 334-339 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	membranous glomerulonephritis anti-phospholipase-a2 receptor antibodies malignancy renal cell carcinoma nephrotic syndrome Diseases of the genitourinary system. Urology RC870-923
spellingShingle	membranous glomerulonephritis anti-phospholipase-a2 receptor antibodies malignancy renal cell carcinoma nephrotic syndrome Diseases of the genitourinary system. Urology RC870-923 Lyle W. Baker Jaime Jimenez-Lopez Xochiquetzal J. Geiger Nabeel Aslam Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection
description	Membranous nephropathy (MN) is currently classified as either primary – often associated with positive anti-phospholipase-A2 receptor (PLA2R) autoantibodies – or as secondary – associated with malignancy, infection, medications, or autoimmune disease. We present a case of biopsy-proven MN with very high serum titer of anti-PLA2R autoantibodies in a patient with a synchronous diagnosis of poorly differentiated esophageal adenocarcinoma and renal cell carcinoma who presented with nephrotic syndrome. Based on the current classification, MN in the presence of active malignancy is diagnosed as secondary and unlikely to have positive anti-PLA2R autoantibodies. This raises several questions: whether this patient has secondary MN associated with malignancy and coincidentally discovered anti-PLA2R autoantibodies, primary MN due to anti-PLA2R autoantibodies with coincidentally discovered malignancy, or whether malignancy can induce the formation of anti-PLA2R autoantibodies that result in MN. This case report highlights the importance of age-appropriate cancer screening, even in patients with presumed primary MN and positive anti-PLA2R autoantibodies.
format	article
author	Lyle W. Baker Jaime Jimenez-Lopez Xochiquetzal J. Geiger Nabeel Aslam
author_facet	Lyle W. Baker Jaime Jimenez-Lopez Xochiquetzal J. Geiger Nabeel Aslam
author_sort	Lyle W. Baker
title	Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection
title_short	Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection
title_full	Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection
title_fullStr	Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection
title_full_unstemmed	Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection
title_sort	malignancy-associated membranous nephropathy with positive anti-pla2r autoantibodies: coincidence or connection
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/233a25bf3d4949f692b2b338038fcfc1
work_keys_str_mv	AT lylewbaker malignancyassociatedmembranousnephropathywithpositiveantipla2rautoantibodiescoincidenceorconnection AT jaimejimenezlopez malignancyassociatedmembranousnephropathywithpositiveantipla2rautoantibodiescoincidenceorconnection AT xochiquetzaljgeiger malignancyassociatedmembranousnephropathywithpositiveantipla2rautoantibodiescoincidenceorconnection AT nabeelaslam malignancyassociatedmembranousnephropathywithpositiveantipla2rautoantibodiescoincidenceorconnection
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Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection

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