TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation

TMBIM6, a member of the transmembrane BI-1 motif-containing family of proteins, is overexpressed in many cancer types. Here, the authors show that TMBIM6 regulates AKT activation through mTORC2 assembly and ribosome association and identify an antagonist of TMBIM6 with anti-tumor properties.

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Autores principales:	Hyun-Kyoung Kim, Kashi Raj Bhattarai, Raghu Patil Junjappa, Jin Hee Ahn, Suvarna H. Pagire, Hyun Ju Yoo, Jaeseok Han, Duckgue Lee, Kyung-Woon Kim, Hyung-Ryong Kim, Han-Jung Chae
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/233adf68c11642c7a91fa75be1d6da5f
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spelling	oai:doaj.org-article:233adf68c11642c7a91fa75be1d6da5f2021-12-02T16:27:46ZTMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation10.1038/s41467-020-17802-42041-1723https://doaj.org/article/233adf68c11642c7a91fa75be1d6da5f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17802-4https://doaj.org/toc/2041-1723TMBIM6, a member of the transmembrane BI-1 motif-containing family of proteins, is overexpressed in many cancer types. Here, the authors show that TMBIM6 regulates AKT activation through mTORC2 assembly and ribosome association and identify an antagonist of TMBIM6 with anti-tumor properties.Hyun-Kyoung KimKashi Raj BhattaraiRaghu Patil JunjappaJin Hee AhnSuvarna H. PagireHyun Ju YooJaeseok HanDuckgue LeeKyung-Woon KimHyung-Ryong KimHan-Jung ChaeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyun-Kyoung Kim Kashi Raj Bhattarai Raghu Patil Junjappa Jin Hee Ahn Suvarna H. Pagire Hyun Ju Yoo Jaeseok Han Duckgue Lee Kyung-Woon Kim Hyung-Ryong Kim Han-Jung Chae TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
description	TMBIM6, a member of the transmembrane BI-1 motif-containing family of proteins, is overexpressed in many cancer types. Here, the authors show that TMBIM6 regulates AKT activation through mTORC2 assembly and ribosome association and identify an antagonist of TMBIM6 with anti-tumor properties.
format	article
author	Hyun-Kyoung Kim Kashi Raj Bhattarai Raghu Patil Junjappa Jin Hee Ahn Suvarna H. Pagire Hyun Ju Yoo Jaeseok Han Duckgue Lee Kyung-Woon Kim Hyung-Ryong Kim Han-Jung Chae
author_facet	Hyun-Kyoung Kim Kashi Raj Bhattarai Raghu Patil Junjappa Jin Hee Ahn Suvarna H. Pagire Hyun Ju Yoo Jaeseok Han Duckgue Lee Kyung-Woon Kim Hyung-Ryong Kim Han-Jung Chae
author_sort	Hyun-Kyoung Kim
title	TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
title_short	TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
title_full	TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
title_fullStr	TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
title_full_unstemmed	TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
title_sort	tmbim6/bi-1 contributes to cancer progression through assembly with mtorc2 and akt activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/233adf68c11642c7a91fa75be1d6da5f
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TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation

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