TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
TMBIM6, a member of the transmembrane BI-1 motif-containing family of proteins, is overexpressed in many cancer types. Here, the authors show that TMBIM6 regulates AKT activation through mTORC2 assembly and ribosome association and identify an antagonist of TMBIM6 with anti-tumor properties.
Guardado en:
Autores principales: | Hyun-Kyoung Kim, Kashi Raj Bhattarai, Raghu Patil Junjappa, Jin Hee Ahn, Suvarna H. Pagire, Hyun Ju Yoo, Jaeseok Han, Duckgue Lee, Kyung-Woon Kim, Hyung-Ryong Kim, Han-Jung Chae |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/233adf68c11642c7a91fa75be1d6da5f |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
por: Xin Zhou, et al.
Publicado: (2020) -
mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Xiaolei Ding, et al.
Publicado: (2016) -
mTORC1 accelerates retinal development via the immunoproteasome
por: Ji-Heon Choi, et al.
Publicado: (2018) -
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
por: Perrine Castets, et al.
Publicado: (2019) -
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
por: Jong Hyun Kim, et al.
Publicado: (2017)