Organization and hierarchy of the human functional brain network lead to a chain-like core

Abstract The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey mat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rossana Mastrandrea, Andrea Gabrielli, Fabrizio Piras, Gianfranco Spalletta, Guido Caldarelli, Tommaso Gili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/233b15c3ef6d4b7d8f8680376f95ae1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:233b15c3ef6d4b7d8f8680376f95ae1c
record_format	dspace
spelling	oai:doaj.org-article:233b15c3ef6d4b7d8f8680376f95ae1c2021-12-02T12:32:55ZOrganization and hierarchy of the human functional brain network lead to a chain-like core10.1038/s41598-017-04716-32045-2322https://doaj.org/article/233b15c3ef6d4b7d8f8680376f95ae1c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04716-3https://doaj.org/toc/2045-2322Abstract The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract information out of the noise. Here we present the analysis of functional magnetic resonance imaging data from forty healthy humans at rest for the investigation of the basal scaffold of the functional brain network organization. We show how brain regions tend to coordinate by forming a highly hierarchical chain-like structure of homogeneously clustered anatomical areas. A maximum spanning tree approach revealed the centrality of the occipital cortex and the peculiar aggregation of cerebellar regions to form a closed core. We also report the hierarchy of network segregation and the level of clusters integration as a function of the connectivity strength between brain regions.Rossana MastrandreaAndrea GabrielliFabrizio PirasGianfranco SpallettaGuido CaldarelliTommaso GiliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rossana Mastrandrea Andrea Gabrielli Fabrizio Piras Gianfranco Spalletta Guido Caldarelli Tommaso Gili Organization and hierarchy of the human functional brain network lead to a chain-like core
description	Abstract The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract information out of the noise. Here we present the analysis of functional magnetic resonance imaging data from forty healthy humans at rest for the investigation of the basal scaffold of the functional brain network organization. We show how brain regions tend to coordinate by forming a highly hierarchical chain-like structure of homogeneously clustered anatomical areas. A maximum spanning tree approach revealed the centrality of the occipital cortex and the peculiar aggregation of cerebellar regions to form a closed core. We also report the hierarchy of network segregation and the level of clusters integration as a function of the connectivity strength between brain regions.
format	article
author	Rossana Mastrandrea Andrea Gabrielli Fabrizio Piras Gianfranco Spalletta Guido Caldarelli Tommaso Gili
author_facet	Rossana Mastrandrea Andrea Gabrielli Fabrizio Piras Gianfranco Spalletta Guido Caldarelli Tommaso Gili
author_sort	Rossana Mastrandrea
title	Organization and hierarchy of the human functional brain network lead to a chain-like core
title_short	Organization and hierarchy of the human functional brain network lead to a chain-like core
title_full	Organization and hierarchy of the human functional brain network lead to a chain-like core
title_fullStr	Organization and hierarchy of the human functional brain network lead to a chain-like core
title_full_unstemmed	Organization and hierarchy of the human functional brain network lead to a chain-like core
title_sort	organization and hierarchy of the human functional brain network lead to a chain-like core
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/233b15c3ef6d4b7d8f8680376f95ae1c
work_keys_str_mv	AT rossanamastrandrea organizationandhierarchyofthehumanfunctionalbrainnetworkleadtoachainlikecore AT andreagabrielli organizationandhierarchyofthehumanfunctionalbrainnetworkleadtoachainlikecore AT fabriziopiras organizationandhierarchyofthehumanfunctionalbrainnetworkleadtoachainlikecore AT gianfrancospalletta organizationandhierarchyofthehumanfunctionalbrainnetworkleadtoachainlikecore AT guidocaldarelli organizationandhierarchyofthehumanfunctionalbrainnetworkleadtoachainlikecore AT tommasogili organizationandhierarchyofthehumanfunctionalbrainnetworkleadtoachainlikecore
_version_	1718393906095194112

Organization and hierarchy of the human functional brain network lead to a chain-like core

Ejemplares similares