Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response

Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to select...

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Main Authors:	Qi Jia, Derek Sieburth
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/2344ed1897b64fa0bd9382bf5d084b8c
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spelling	oai:doaj.org-article:2344ed1897b64fa0bd9382bf5d084b8c2021-12-02T14:25:17ZMitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response10.1038/s41467-021-22561-x2041-1723https://doaj.org/article/2344ed1897b64fa0bd9382bf5d084b8c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22561-xhttps://doaj.org/toc/2041-1723Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to selectively regulate neuropeptide secretion in C. elegans.Qi JiaDerek SieburthNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Jia Derek Sieburth Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
description	Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, though underlying mechanisms remain unknown. Here the authors show that endogenously produced hydrogen peroxide originating from axonal mitochondria functions as a signaling cue to selectively regulate neuropeptide secretion in C. elegans.
format	article
author	Qi Jia Derek Sieburth
author_facet	Qi Jia Derek Sieburth
author_sort	Qi Jia
title	Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_short	Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_full	Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_fullStr	Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_full_unstemmed	Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
title_sort	mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2344ed1897b64fa0bd9382bf5d084b8c
work_keys_str_mv	AT qijia mitochondrialhydrogenperoxidepositivelyregulatesneuropeptidesecretionduringdietinducedactivationoftheoxidativestressresponse AT dereksieburth mitochondrialhydrogenperoxidepositivelyregulatesneuropeptidesecretionduringdietinducedactivationoftheoxidativestressresponse
_version_	1718391357803855872

Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response

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