Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape

Ali Kermanizadeh,1,2 Leagh G Powell,1 Vicki Stone,1 Peter Møller2 1NanoSafety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; 2Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark...

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Autores principales:	Kermanizadeh A, Powell LG, Stone V, Møller P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Nanomedicine oral route of exposure nanomaterials toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/23450899ddbe4f67bd39811302397d06
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spelling	oai:doaj.org-article:23450899ddbe4f67bd39811302397d062021-12-02T07:57:32ZNanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape1178-2013https://doaj.org/article/23450899ddbe4f67bd39811302397d062018-11-01T00:00:00Zhttps://www.dovepress.com/nanodelivery-systems-and-stabilized-solid-drug-nanoparticles-for-orall-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ali Kermanizadeh,1,2 Leagh G Powell,1 Vicki Stone,1 Peter Møller2 1NanoSafety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; 2Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark Abstract: The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications. Keywords: nanomedicine, oral route of delivery, nanomaterials, nano-stabilized solid drugsKermanizadeh APowell LGStone VMøller PDove Medical PressarticleNanomedicineoral route of exposurenanomaterialstoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7575-7605 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanomedicine oral route of exposure nanomaterials toxicity Medicine (General) R5-920
spellingShingle	Nanomedicine oral route of exposure nanomaterials toxicity Medicine (General) R5-920 Kermanizadeh A Powell LG Stone V Møller P Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
description	Ali Kermanizadeh,1,2 Leagh G Powell,1 Vicki Stone,1 Peter Møller2 1NanoSafety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; 2Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark Abstract: The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications. Keywords: nanomedicine, oral route of delivery, nanomaterials, nano-stabilized solid drugs
format	article
author	Kermanizadeh A Powell LG Stone V Møller P
author_facet	Kermanizadeh A Powell LG Stone V Møller P
author_sort	Kermanizadeh A
title	Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
title_short	Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
title_full	Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
title_fullStr	Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
title_full_unstemmed	Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
title_sort	nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/23450899ddbe4f67bd39811302397d06
work_keys_str_mv	AT kermanizadeha nanodeliverysystemsandstabilizedsoliddrugnanoparticlesfororallyadministeredmedicinecurrentlandscape AT powelllg nanodeliverysystemsandstabilizedsoliddrugnanoparticlesfororallyadministeredmedicinecurrentlandscape AT stonev nanodeliverysystemsandstabilizedsoliddrugnanoparticlesfororallyadministeredmedicinecurrentlandscape AT møllerp nanodeliverysystemsandstabilizedsoliddrugnanoparticlesfororallyadministeredmedicinecurrentlandscape
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Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape

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