Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome

Children with Down syndrome (DS) are at high risk for developing obstructive sleep apnea (OSA) compared to children without DS. The negative impact of OSA on health, behavior, and cognitive development in children with DS highlights the importance of timely and effective treatment. Due to the higher...

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Autores principales:	Erica Gastelum, Marcus Cummins, Amitoj Singh, Michael Montoya, Gino Luis Urbano, Mary Anne Tablizo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obstructive sleep apnea Down syndrome trisomy 21 pediatric adenotonsillectomy continuous positive airway pressure Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/2345bbca238b4869bdbe1026181cbf0f
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spelling	oai:doaj.org-article:2345bbca238b4869bdbe1026181cbf0f2021-11-25T17:15:10ZTreatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome10.3390/children81110742227-9067https://doaj.org/article/2345bbca238b4869bdbe1026181cbf0f2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1074https://doaj.org/toc/2227-9067Children with Down syndrome (DS) are at high risk for developing obstructive sleep apnea (OSA) compared to children without DS. The negative impact of OSA on health, behavior, and cognitive development in children with DS highlights the importance of timely and effective treatment. Due to the higher prevalence of craniofacial and airway abnormalities, obesity, and hypotonia in patients with DS, residual OSA can still occur after exhausting first-line options. While treatment commonly includes adenotonsillectomy (AT) and continuous positive airway pressure (CPAP) therapy, additional therapy such as medical management and/or adjuvant surgical procedures need to be considered in refractory OSA. Given the significant comorbidities secondary to untreated OSA in children with DS, such as cardiovascular and neurobehavioral consequences, more robust randomized trials in this patient population are needed to produce treatment guidelines separate from those for the general pediatric population of otherwise healthy children with OSA. Further studies are also needed to look at desensitization and optimization of CPAP use in patients with DS and OSA.Erica GastelumMarcus CumminsAmitoj SinghMichael MontoyaGino Luis UrbanoMary Anne TablizoMDPI AGarticleobstructive sleep apneaDown syndrometrisomy 21pediatricadenotonsillectomycontinuous positive airway pressurePediatricsRJ1-570ENChildren, Vol 8, Iss 1074, p 1074 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea Down syndrome trisomy 21 pediatric adenotonsillectomy continuous positive airway pressure Pediatrics RJ1-570
spellingShingle	obstructive sleep apnea Down syndrome trisomy 21 pediatric adenotonsillectomy continuous positive airway pressure Pediatrics RJ1-570 Erica Gastelum Marcus Cummins Amitoj Singh Michael Montoya Gino Luis Urbano Mary Anne Tablizo Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome
description	Children with Down syndrome (DS) are at high risk for developing obstructive sleep apnea (OSA) compared to children without DS. The negative impact of OSA on health, behavior, and cognitive development in children with DS highlights the importance of timely and effective treatment. Due to the higher prevalence of craniofacial and airway abnormalities, obesity, and hypotonia in patients with DS, residual OSA can still occur after exhausting first-line options. While treatment commonly includes adenotonsillectomy (AT) and continuous positive airway pressure (CPAP) therapy, additional therapy such as medical management and/or adjuvant surgical procedures need to be considered in refractory OSA. Given the significant comorbidities secondary to untreated OSA in children with DS, such as cardiovascular and neurobehavioral consequences, more robust randomized trials in this patient population are needed to produce treatment guidelines separate from those for the general pediatric population of otherwise healthy children with OSA. Further studies are also needed to look at desensitization and optimization of CPAP use in patients with DS and OSA.
format	article
author	Erica Gastelum Marcus Cummins Amitoj Singh Michael Montoya Gino Luis Urbano Mary Anne Tablizo
author_facet	Erica Gastelum Marcus Cummins Amitoj Singh Michael Montoya Gino Luis Urbano Mary Anne Tablizo
author_sort	Erica Gastelum
title	Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome
title_short	Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome
title_full	Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome
title_fullStr	Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome
title_full_unstemmed	Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome
title_sort	treatment considerations for obstructive sleep apnea in pediatric down syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2345bbca238b4869bdbe1026181cbf0f
work_keys_str_mv	AT ericagastelum treatmentconsiderationsforobstructivesleepapneainpediatricdownsyndrome AT marcuscummins treatmentconsiderationsforobstructivesleepapneainpediatricdownsyndrome AT amitojsingh treatmentconsiderationsforobstructivesleepapneainpediatricdownsyndrome AT michaelmontoya treatmentconsiderationsforobstructivesleepapneainpediatricdownsyndrome AT ginoluisurbano treatmentconsiderationsforobstructivesleepapneainpediatricdownsyndrome AT maryannetablizo treatmentconsiderationsforobstructivesleepapneainpediatricdownsyndrome
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Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome

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