Modelling proteins’ hidden conformations to predict antibiotic resistance
Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity.
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Nature Portfolio
2016
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oai:doaj.org-article:234708999b6a401a85bad9993edf6cfe2021-12-02T16:49:25ZModelling proteins’ hidden conformations to predict antibiotic resistance10.1038/ncomms129652041-1723https://doaj.org/article/234708999b6a401a85bad9993edf6cfe2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12965https://doaj.org/toc/2041-1723Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity.Kathryn M. HartChris M. W. HoSupratik DuttaMichael L. GrossGregory R. BowmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q |
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Science Q Kathryn M. Hart Chris M. W. Ho Supratik Dutta Michael L. Gross Gregory R. Bowman Modelling proteins’ hidden conformations to predict antibiotic resistance |
description |
Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity. |
format |
article |
author |
Kathryn M. Hart Chris M. W. Ho Supratik Dutta Michael L. Gross Gregory R. Bowman |
author_facet |
Kathryn M. Hart Chris M. W. Ho Supratik Dutta Michael L. Gross Gregory R. Bowman |
author_sort |
Kathryn M. Hart |
title |
Modelling proteins’ hidden conformations to predict antibiotic resistance |
title_short |
Modelling proteins’ hidden conformations to predict antibiotic resistance |
title_full |
Modelling proteins’ hidden conformations to predict antibiotic resistance |
title_fullStr |
Modelling proteins’ hidden conformations to predict antibiotic resistance |
title_full_unstemmed |
Modelling proteins’ hidden conformations to predict antibiotic resistance |
title_sort |
modelling proteins’ hidden conformations to predict antibiotic resistance |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/234708999b6a401a85bad9993edf6cfe |
work_keys_str_mv |
AT kathrynmhart modellingproteinshiddenconformationstopredictantibioticresistance AT chrismwho modellingproteinshiddenconformationstopredictantibioticresistance AT supratikdutta modellingproteinshiddenconformationstopredictantibioticresistance AT michaellgross modellingproteinshiddenconformationstopredictantibioticresistance AT gregoryrbowman modellingproteinshiddenconformationstopredictantibioticresistance |
_version_ |
1718383322388758528 |