Modelling proteins’ hidden conformations to predict antibiotic resistance

Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity.

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Autores principales:	Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross, Gregory R. Bowman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/234708999b6a401a85bad9993edf6cfe
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id	oai:doaj.org-article:234708999b6a401a85bad9993edf6cfe
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spelling	oai:doaj.org-article:234708999b6a401a85bad9993edf6cfe2021-12-02T16:49:25ZModelling proteins’ hidden conformations to predict antibiotic resistance10.1038/ncomms129652041-1723https://doaj.org/article/234708999b6a401a85bad9993edf6cfe2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12965https://doaj.org/toc/2041-1723Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity.Kathryn M. HartChris M. W. HoSupratik DuttaMichael L. GrossGregory R. BowmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathryn M. Hart Chris M. W. Ho Supratik Dutta Michael L. Gross Gregory R. Bowman Modelling proteins’ hidden conformations to predict antibiotic resistance
description	Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM substrate specificity.
format	article
author	Kathryn M. Hart Chris M. W. Ho Supratik Dutta Michael L. Gross Gregory R. Bowman
author_facet	Kathryn M. Hart Chris M. W. Ho Supratik Dutta Michael L. Gross Gregory R. Bowman
author_sort	Kathryn M. Hart
title	Modelling proteins’ hidden conformations to predict antibiotic resistance
title_short	Modelling proteins’ hidden conformations to predict antibiotic resistance
title_full	Modelling proteins’ hidden conformations to predict antibiotic resistance
title_fullStr	Modelling proteins’ hidden conformations to predict antibiotic resistance
title_full_unstemmed	Modelling proteins’ hidden conformations to predict antibiotic resistance
title_sort	modelling proteins’ hidden conformations to predict antibiotic resistance
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/234708999b6a401a85bad9993edf6cfe
work_keys_str_mv	AT kathrynmhart modellingproteinshiddenconformationstopredictantibioticresistance AT chrismwho modellingproteinshiddenconformationstopredictantibioticresistance AT supratikdutta modellingproteinshiddenconformationstopredictantibioticresistance AT michaellgross modellingproteinshiddenconformationstopredictantibioticresistance AT gregoryrbowman modellingproteinshiddenconformationstopredictantibioticresistance
_version_	1718383322388758528

Modelling proteins’ hidden conformations to predict antibiotic resistance

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