Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells

The eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) formulation with a ratio of 6:1 is a potent stimulator of the endothelial formation of nitric oxide (NO). The aim of the study was to investigate whether nanoencapsulation of EPA:DHA 6:1 followed by coating with gum increases its biologi...

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Autores principales:	L. Remila, E. Belcastro, N. Guenday-Tuereli, S. Park, U. Houngue, T. Vandamme, E. Tuereli, P. Kerth, C. Auger, V. Schini-Kerth
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Omega-3 Nanoencapsulation EPA:DHA 6:1 Endothelium Nitric oxide Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/2347271eb122473e919adf113b841730
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spelling	oai:doaj.org-article:2347271eb122473e919adf113b8417302021-11-14T04:31:23ZNanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells1756-464610.1016/j.jff.2021.104851https://doaj.org/article/2347271eb122473e919adf113b8417302021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005004https://doaj.org/toc/1756-4646The eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) formulation with a ratio of 6:1 is a potent stimulator of the endothelial formation of nitric oxide (NO). The aim of the study was to investigate whether nanoencapsulation of EPA:DHA 6:1 followed by coating with gum increases its biological activity. Vascular reactivity was assessed using porcine coronary artery rings, the formation of NO in cultured endothelial cells (ECs) using DAF-FM and indirectly by platelet aggregation studies. Coated EPA:DHA 6:1 nanoparticles induced sustained relaxations of coronary artery rings that were greater in rings with than in those without endothelium, and more pronounced than with the native form. Treatment of ECs with coated EPA:DHA 6:1 nanoparticles caused greater and more sustained formation of NO and enhanced their anti-aggregatory effects. Thus, nanoencapsulation of EPA:DHA 6:1 is an attractive strategy to enhance the beneficial effect at the vascular endothelium.L. RemilaE. BelcastroN. Guenday-TuereliS. ParkU. HoungueT. VandammeE. TuereliP. KerthC. AugerV. Schini-KerthElsevierarticleOmega-3NanoencapsulationEPA:DHA 6:1EndotheliumNitric oxideNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104851- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Omega-3 Nanoencapsulation EPA:DHA 6:1 Endothelium Nitric oxide Nutrition. Foods and food supply TX341-641
spellingShingle	Omega-3 Nanoencapsulation EPA:DHA 6:1 Endothelium Nitric oxide Nutrition. Foods and food supply TX341-641 L. Remila E. Belcastro N. Guenday-Tuereli S. Park U. Houngue T. Vandamme E. Tuereli P. Kerth C. Auger V. Schini-Kerth Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells
description	The eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) formulation with a ratio of 6:1 is a potent stimulator of the endothelial formation of nitric oxide (NO). The aim of the study was to investigate whether nanoencapsulation of EPA:DHA 6:1 followed by coating with gum increases its biological activity. Vascular reactivity was assessed using porcine coronary artery rings, the formation of NO in cultured endothelial cells (ECs) using DAF-FM and indirectly by platelet aggregation studies. Coated EPA:DHA 6:1 nanoparticles induced sustained relaxations of coronary artery rings that were greater in rings with than in those without endothelium, and more pronounced than with the native form. Treatment of ECs with coated EPA:DHA 6:1 nanoparticles caused greater and more sustained formation of NO and enhanced their anti-aggregatory effects. Thus, nanoencapsulation of EPA:DHA 6:1 is an attractive strategy to enhance the beneficial effect at the vascular endothelium.
format	article
author	L. Remila E. Belcastro N. Guenday-Tuereli S. Park U. Houngue T. Vandamme E. Tuereli P. Kerth C. Auger V. Schini-Kerth
author_facet	L. Remila E. Belcastro N. Guenday-Tuereli S. Park U. Houngue T. Vandamme E. Tuereli P. Kerth C. Auger V. Schini-Kerth
author_sort	L. Remila
title	Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells
title_short	Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells
title_full	Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells
title_fullStr	Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells
title_full_unstemmed	Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells
title_sort	nanoencapsulation of the omega-3 epa:dha 6:1 formulation enhances and sustains no-mediated endothelium-dependent relaxations in coronary artery rings and no formation in endothelial cells
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2347271eb122473e919adf113b841730
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Nanoencapsulation of the omega-3 EPA:DHA 6:1 formulation enhances and sustains NO-mediated endothelium-dependent relaxations in coronary artery rings and NO formation in endothelial cells

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