Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration

Douglas A Katsev,1 Cailyn C Katsev,1 Jen Pinnow,2 Catherine M Lockhart3 1Santa Barbara Surgery Center, Santa Barbara, CA, 2Pinnow Consulting, Bellingham, WA, 3Omeros Corporation, seattle, WA, USA Purpose: To evaluate the intracameral concentration of ketorolac tromethamine (ketorolac) at the begi...

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Autores principales:	Katsev DA, Katsev CC, Pinnow J, Lockhart CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Cataract surgery NSAIDs ketorolac topical administration intracameral drug concentration Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/234bb9dd37354623b517a1c6bfeab085
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spelling	oai:doaj.org-article:234bb9dd37354623b517a1c6bfeab0852021-12-02T03:39:39ZIntracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration1177-5483https://doaj.org/article/234bb9dd37354623b517a1c6bfeab0852017-10-01T00:00:00Zhttps://www.dovepress.com/intracameral-ketorolac-concentration-at-the-beginning-and-end-of-catar-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Douglas A Katsev,1 Cailyn C Katsev,1 Jen Pinnow,2 Catherine M Lockhart3 1Santa Barbara Surgery Center, Santa Barbara, CA, 2Pinnow Consulting, Bellingham, WA, 3Omeros Corporation, seattle, WA, USA Purpose: To evaluate the intracameral concentration of ketorolac tromethamine (ketorolac) at the beginning and end of cataract surgery following preoperative topical administration.Setting: Santa Barbara Surgery Center, Santa Barbara, CA, USA.Design: This was a pre–post, interventional, single-arm study.Patients and methods: Patients undergoing cataract extraction and lens replacement (CELR) were eligible. Written informed consent was obtained from 14 patients who were prescribed topical ophthalmic ketorolac according to the surgeon’s usual practice beginning the day prior to surgery. The surgeon withdrew 100 µL of aqueous humor from the operative eye immediately prior to the initial surgical incision and again just prior to final anterior chamber reinflation and wound closure. Ketorolac concentrations in the intracameral fluid samples were measured.Results: Thirteen of 14 patients used four doses of ketorolac the day prior to surgery as directed, and one patient used three doses. On the day of surgery, all 14 patients administered one drop of topical ketorolac on awakening and one drop after arriving at the surgery center. Preoperative ketorolac concentrations for the 12 patients from whom samples were collected ranged from 4.9 to 369 ng/mL. End-of-procedure sample concentrations ranged from <1.0 (the lower limit of quantification [LLOQ]) to 6.32 ng/mL, with eight of 12 patients having ketorolac levels below the LLOQ. Conclusion: At-home compliance with topical ketorolac was good, with 92.9% of patients using it as directed. Following CELR, levels of ketorolac in the aqueous humor were low, and 66.7% of patients had undetectable levels. Keywords: cataract surgery, NSAIDs, ketorolac, topical administration, intracameral drug concentrationKatsev DAKatsev CCPinnow JLockhart CMDove Medical PressarticleCataract surgeryNSAIDsketorolactopical administrationintracameral drug concentrationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1897-1901 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cataract surgery NSAIDs ketorolac topical administration intracameral drug concentration Ophthalmology RE1-994
spellingShingle	Cataract surgery NSAIDs ketorolac topical administration intracameral drug concentration Ophthalmology RE1-994 Katsev DA Katsev CC Pinnow J Lockhart CM Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
description	Douglas A Katsev,1 Cailyn C Katsev,1 Jen Pinnow,2 Catherine M Lockhart3 1Santa Barbara Surgery Center, Santa Barbara, CA, 2Pinnow Consulting, Bellingham, WA, 3Omeros Corporation, seattle, WA, USA Purpose: To evaluate the intracameral concentration of ketorolac tromethamine (ketorolac) at the beginning and end of cataract surgery following preoperative topical administration.Setting: Santa Barbara Surgery Center, Santa Barbara, CA, USA.Design: This was a pre–post, interventional, single-arm study.Patients and methods: Patients undergoing cataract extraction and lens replacement (CELR) were eligible. Written informed consent was obtained from 14 patients who were prescribed topical ophthalmic ketorolac according to the surgeon’s usual practice beginning the day prior to surgery. The surgeon withdrew 100 µL of aqueous humor from the operative eye immediately prior to the initial surgical incision and again just prior to final anterior chamber reinflation and wound closure. Ketorolac concentrations in the intracameral fluid samples were measured.Results: Thirteen of 14 patients used four doses of ketorolac the day prior to surgery as directed, and one patient used three doses. On the day of surgery, all 14 patients administered one drop of topical ketorolac on awakening and one drop after arriving at the surgery center. Preoperative ketorolac concentrations for the 12 patients from whom samples were collected ranged from 4.9 to 369 ng/mL. End-of-procedure sample concentrations ranged from <1.0 (the lower limit of quantification [LLOQ]) to 6.32 ng/mL, with eight of 12 patients having ketorolac levels below the LLOQ. Conclusion: At-home compliance with topical ketorolac was good, with 92.9% of patients using it as directed. Following CELR, levels of ketorolac in the aqueous humor were low, and 66.7% of patients had undetectable levels. Keywords: cataract surgery, NSAIDs, ketorolac, topical administration, intracameral drug concentration
format	article
author	Katsev DA Katsev CC Pinnow J Lockhart CM
author_facet	Katsev DA Katsev CC Pinnow J Lockhart CM
author_sort	Katsev DA
title	Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
title_short	Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
title_full	Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
title_fullStr	Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
title_full_unstemmed	Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
title_sort	intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/234bb9dd37354623b517a1c6bfeab085
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Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration

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