Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight

Abstract Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between...

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Autores principales:	Angelique Van Ombergen, Floris L. Wuyts, Ben Jeurissen, Jan Sijbers, Floris Vanhevel, Steven Jillings, Paul M. Parizel, Stefan Sunaert, Paul H. Van de Heyning, Vincent Dousset, Steven Laureys, Athena Demertzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/234ffb532f794af7a34153f2546ab2ef
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spelling	oai:doaj.org-article:234ffb532f794af7a34153f2546ab2ef2021-12-02T11:52:14ZIntrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight10.1038/s41598-017-03170-52045-2322https://doaj.org/article/234ffb532f794af7a34153f2546ab2ef2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03170-5https://doaj.org/toc/2045-2322Abstract Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine effects, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and self-related functions. Our findings shed light on how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness.Angelique Van OmbergenFloris L. WuytsBen JeurissenJan SijbersFloris VanhevelSteven JillingsPaul M. ParizelStefan SunaertPaul H. Van de HeyningVincent DoussetSteven LaureysAthena DemertziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angelique Van Ombergen Floris L. Wuyts Ben Jeurissen Jan Sijbers Floris Vanhevel Steven Jillings Paul M. Parizel Stefan Sunaert Paul H. Van de Heyning Vincent Dousset Steven Laureys Athena Demertzi Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
description	Abstract Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine effects, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and self-related functions. Our findings shed light on how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness.
format	article
author	Angelique Van Ombergen Floris L. Wuyts Ben Jeurissen Jan Sijbers Floris Vanhevel Steven Jillings Paul M. Parizel Stefan Sunaert Paul H. Van de Heyning Vincent Dousset Steven Laureys Athena Demertzi
author_facet	Angelique Van Ombergen Floris L. Wuyts Ben Jeurissen Jan Sijbers Floris Vanhevel Steven Jillings Paul M. Parizel Stefan Sunaert Paul H. Van de Heyning Vincent Dousset Steven Laureys Athena Demertzi
author_sort	Angelique Van Ombergen
title	Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_short	Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_full	Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_fullStr	Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_full_unstemmed	Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_sort	intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/234ffb532f794af7a34153f2546ab2ef
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Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight

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