Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight

Abstract Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between...

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Autores principales: Angelique Van Ombergen, Floris L. Wuyts, Ben Jeurissen, Jan Sijbers, Floris Vanhevel, Steven Jillings, Paul M. Parizel, Stefan Sunaert, Paul H. Van de Heyning, Vincent Dousset, Steven Laureys, Athena Demertzi
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/234ffb532f794af7a34153f2546ab2ef
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spelling oai:doaj.org-article:234ffb532f794af7a34153f2546ab2ef2021-12-02T11:52:14ZIntrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight10.1038/s41598-017-03170-52045-2322https://doaj.org/article/234ffb532f794af7a34153f2546ab2ef2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03170-5https://doaj.org/toc/2045-2322Abstract Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine effects, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and self-related functions. Our findings shed light on how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness.Angelique Van OmbergenFloris L. WuytsBen JeurissenJan SijbersFloris VanhevelSteven JillingsPaul M. ParizelStefan SunaertPaul H. Van de HeyningVincent DoussetSteven LaureysAthena DemertziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Angelique Van Ombergen
Floris L. Wuyts
Ben Jeurissen
Jan Sijbers
Floris Vanhevel
Steven Jillings
Paul M. Parizel
Stefan Sunaert
Paul H. Van de Heyning
Vincent Dousset
Steven Laureys
Athena Demertzi
Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
description Abstract Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine effects, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and self-related functions. Our findings shed light on how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness.
format article
author Angelique Van Ombergen
Floris L. Wuyts
Ben Jeurissen
Jan Sijbers
Floris Vanhevel
Steven Jillings
Paul M. Parizel
Stefan Sunaert
Paul H. Van de Heyning
Vincent Dousset
Steven Laureys
Athena Demertzi
author_facet Angelique Van Ombergen
Floris L. Wuyts
Ben Jeurissen
Jan Sijbers
Floris Vanhevel
Steven Jillings
Paul M. Parizel
Stefan Sunaert
Paul H. Van de Heyning
Vincent Dousset
Steven Laureys
Athena Demertzi
author_sort Angelique Van Ombergen
title Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_short Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_full Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_fullStr Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_full_unstemmed Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
title_sort intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/234ffb532f794af7a34153f2546ab2ef
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