Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

SAMHD1 catalyses the dephosphorylation of deoxynucleotide triphosphates (dNTPs) and has antiretroviral activity. Here, the authors present the crystal structures of SAMHD1-oligonucleotide complexes, which reveal that the allosteric binding sites of SAMHD1 are plastic and can fit oligonucleotides in...

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Autores principales:	Corey H. Yu, Akash Bhattacharya, Mirjana Persaud, Alexander B. Taylor, Zhonghua Wang, Angel Bulnes-Ramos, Joella Xu, Anastasia Selyutina, Alicia Martinez-Lopez, Kristin Cano, Borries Demeler, Baek Kim, Stephen C. Hardies, Felipe Diaz-Griffero, Dmitri N. Ivanov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/235030ae21f844b790931e36a84dca12
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spelling	oai:doaj.org-article:235030ae21f844b790931e36a84dca122021-12-02T10:44:12ZNucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification10.1038/s41467-021-21023-82041-1723https://doaj.org/article/235030ae21f844b790931e36a84dca122021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21023-8https://doaj.org/toc/2041-1723SAMHD1 catalyses the dephosphorylation of deoxynucleotide triphosphates (dNTPs) and has antiretroviral activity. Here, the authors present the crystal structures of SAMHD1-oligonucleotide complexes, which reveal that the allosteric binding sites of SAMHD1 are plastic and can fit oligonucleotides in place of the two allosteric activators GTP and dNTP, and they also show that SAMHD1 recognises GpsN phosphorothioation modifications in nucleic acids, which is of interest in drug design.Corey H. YuAkash BhattacharyaMirjana PersaudAlexander B. TaylorZhonghua WangAngel Bulnes-RamosJoella XuAnastasia SelyutinaAlicia Martinez-LopezKristin CanoBorries DemelerBaek KimStephen C. HardiesFelipe Diaz-GrifferoDmitri N. IvanovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Corey H. Yu Akash Bhattacharya Mirjana Persaud Alexander B. Taylor Zhonghua Wang Angel Bulnes-Ramos Joella Xu Anastasia Selyutina Alicia Martinez-Lopez Kristin Cano Borries Demeler Baek Kim Stephen C. Hardies Felipe Diaz-Griffero Dmitri N. Ivanov Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
description	SAMHD1 catalyses the dephosphorylation of deoxynucleotide triphosphates (dNTPs) and has antiretroviral activity. Here, the authors present the crystal structures of SAMHD1-oligonucleotide complexes, which reveal that the allosteric binding sites of SAMHD1 are plastic and can fit oligonucleotides in place of the two allosteric activators GTP and dNTP, and they also show that SAMHD1 recognises GpsN phosphorothioation modifications in nucleic acids, which is of interest in drug design.
format	article
author	Corey H. Yu Akash Bhattacharya Mirjana Persaud Alexander B. Taylor Zhonghua Wang Angel Bulnes-Ramos Joella Xu Anastasia Selyutina Alicia Martinez-Lopez Kristin Cano Borries Demeler Baek Kim Stephen C. Hardies Felipe Diaz-Griffero Dmitri N. Ivanov
author_facet	Corey H. Yu Akash Bhattacharya Mirjana Persaud Alexander B. Taylor Zhonghua Wang Angel Bulnes-Ramos Joella Xu Anastasia Selyutina Alicia Martinez-Lopez Kristin Cano Borries Demeler Baek Kim Stephen C. Hardies Felipe Diaz-Griffero Dmitri N. Ivanov
author_sort	Corey H. Yu
title	Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
title_short	Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
title_full	Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
title_fullStr	Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
title_full_unstemmed	Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
title_sort	nucleic acid binding by samhd1 contributes to the antiretroviral activity and is enhanced by the gpsn modification
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/235030ae21f844b790931e36a84dca12
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Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

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