Structural basis for genome packaging, retention, and ejection in human cytomegalovirus

Human cytomegalovirus (HCMV) is the prototypical member of the β-herpesvirinae subfamily and the leading viral cause of congenital infections that can lead to birth defects and it can also cause life-threatening disease in immunocompromised individuals. Here, the authors present the in-situ cryo-EM...

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Autores principales:	Zhihai Li, Jingjing Pang, Lili Dong, Xuekui Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23556ba7f86c486d8c97a3c6a4e69b3b
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spelling	oai:doaj.org-article:23556ba7f86c486d8c97a3c6a4e69b3b2021-12-02T16:25:00ZStructural basis for genome packaging, retention, and ejection in human cytomegalovirus10.1038/s41467-021-24820-32041-1723https://doaj.org/article/23556ba7f86c486d8c97a3c6a4e69b3b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24820-3https://doaj.org/toc/2041-1723Human cytomegalovirus (HCMV) is the prototypical member of the β-herpesvirinae subfamily and the leading viral cause of congenital infections that can lead to birth defects and it can also cause life-threatening disease in immunocompromised individuals. Here, the authors present the in-situ cryo-EM structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV and discuss the mechanistic implications for genome package, retention and ejection.Zhihai LiJingjing PangLili DongXuekui YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhihai Li Jingjing Pang Lili Dong Xuekui Yu Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
description	Human cytomegalovirus (HCMV) is the prototypical member of the β-herpesvirinae subfamily and the leading viral cause of congenital infections that can lead to birth defects and it can also cause life-threatening disease in immunocompromised individuals. Here, the authors present the in-situ cryo-EM structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV and discuss the mechanistic implications for genome package, retention and ejection.
format	article
author	Zhihai Li Jingjing Pang Lili Dong Xuekui Yu
author_facet	Zhihai Li Jingjing Pang Lili Dong Xuekui Yu
author_sort	Zhihai Li
title	Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
title_short	Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
title_full	Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
title_fullStr	Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
title_full_unstemmed	Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
title_sort	structural basis for genome packaging, retention, and ejection in human cytomegalovirus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23556ba7f86c486d8c97a3c6a4e69b3b
work_keys_str_mv	AT zhihaili structuralbasisforgenomepackagingretentionandejectioninhumancytomegalovirus AT jingjingpang structuralbasisforgenomepackagingretentionandejectioninhumancytomegalovirus AT lilidong structuralbasisforgenomepackagingretentionandejectioninhumancytomegalovirus AT xuekuiyu structuralbasisforgenomepackagingretentionandejectioninhumancytomegalovirus
_version_	1718384039095697408

Structural basis for genome packaging, retention, and ejection in human cytomegalovirus

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