Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as <i>Inula viscosa</i>. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels rangin...

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Autores principales:	Nasreddine El Omari, Naoual El Menyiy, Gokhan Zengin, Bey Hing Goh, Monica Gallo, Domenico Montesano, Daniele Naviglio, Abdelhakim Bouyahya
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tomentosin cancer inflammation telomerase apoptosis NF-κB Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2356b188ae2d401c8157160c62818ef2
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spelling	oai:doaj.org-article:2356b188ae2d401c8157160c62818ef22021-11-25T18:59:22ZAnticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms10.3390/separations81102072297-8739https://doaj.org/article/2356b188ae2d401c8157160c62818ef22021-11-01T00:00:00Zhttps://www.mdpi.com/2297-8739/8/11/207https://doaj.org/toc/2297-8739Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as <i>Inula viscosa</i>. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels ranging from cellular organization to molecular transcriptional factors and epigenetic modifications. Tomentosin’s possession of the modulatory effect on telomerase expression on tumor cell lines has captured the interest of researchers and spurred a more robust study on its anticancer effect. Since inflammation has a close link with cancer disease, this natural compound appears to be a potential cancer-fighting drug. Indeed, its recently demonstrated anti-inflammatory action can be considered as a starting point for its evaluation as an anticancer chemo-preventive agentNasreddine El OmariNaoual El MenyiyGokhan ZenginBey Hing GohMonica GalloDomenico MontesanoDaniele NaviglioAbdelhakim BouyahyaMDPI AGarticletomentosincancerinflammationtelomeraseapoptosisNF-κBPhysicsQC1-999ChemistryQD1-999ENSeparations, Vol 8, Iss 207, p 207 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tomentosin cancer inflammation telomerase apoptosis NF-κB Physics QC1-999 Chemistry QD1-999
spellingShingle	tomentosin cancer inflammation telomerase apoptosis NF-κB Physics QC1-999 Chemistry QD1-999 Nasreddine El Omari Naoual El Menyiy Gokhan Zengin Bey Hing Goh Monica Gallo Domenico Montesano Daniele Naviglio Abdelhakim Bouyahya Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
description	Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as <i>Inula viscosa</i>. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels ranging from cellular organization to molecular transcriptional factors and epigenetic modifications. Tomentosin’s possession of the modulatory effect on telomerase expression on tumor cell lines has captured the interest of researchers and spurred a more robust study on its anticancer effect. Since inflammation has a close link with cancer disease, this natural compound appears to be a potential cancer-fighting drug. Indeed, its recently demonstrated anti-inflammatory action can be considered as a starting point for its evaluation as an anticancer chemo-preventive agent
format	article
author	Nasreddine El Omari Naoual El Menyiy Gokhan Zengin Bey Hing Goh Monica Gallo Domenico Montesano Daniele Naviglio Abdelhakim Bouyahya
author_facet	Nasreddine El Omari Naoual El Menyiy Gokhan Zengin Bey Hing Goh Monica Gallo Domenico Montesano Daniele Naviglio Abdelhakim Bouyahya
author_sort	Nasreddine El Omari
title	Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
title_short	Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
title_full	Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
title_fullStr	Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
title_full_unstemmed	Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms
title_sort	anticancer and anti-inflammatory effects of tomentosin: cellular and molecular mechanisms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2356b188ae2d401c8157160c62818ef2
work_keys_str_mv	AT nasreddineelomari anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT naoualelmenyiy anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT gokhanzengin anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT beyhinggoh anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT monicagallo anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT domenicomontesano anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT danielenaviglio anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms AT abdelhakimbouyahya anticancerandantiinflammatoryeffectsoftomentosincellularandmolecularmechanisms
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Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

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