Non-genetic determinants of mosquito competence for malaria parasites.

Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., ve...

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Autores principales:	Thierry Lefèvre, Amélie Vantaux, Kounbobr R Dabiré, Karine Mouline, Anna Cohuet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/235790ed586c44ea92a3254815c7a584
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spelling	oai:doaj.org-article:235790ed586c44ea92a3254815c7a5842021-11-18T06:05:31ZNon-genetic determinants of mosquito competence for malaria parasites.1553-73661553-737410.1371/journal.ppat.1003365https://doaj.org/article/235790ed586c44ea92a3254815c7a5842013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23818841/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., vector competence. Although the role of environment has long been recognized, much work has focused on host and parasite genetic effects. However, the last few years have seen a surge of studies revealing a great diversity of ways in which non-genetic factors can interfere with mosquito-Plasmodium interactions. Here, we review the current evidence for such environmentally mediated effects, including ambient temperature, mosquito diet, microbial gut flora, and infection history, and we identify additional factors previously overlooked in mosquito-Plasmodium interactions. We also discuss epidemiological implications, and the evolutionary consequences for vector immunity and parasite transmission strategies. Finally, we propose directions for further research and argue that an improved knowledge of non-genetic influences on mosquito-Plasmodium interactions could aid in implementing conventional malaria control measures and contribute to the design of novel strategies.Thierry LefèvreAmélie VantauxKounbobr R DabiréKarine MoulineAnna CohuetPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 6, p e1003365 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Thierry Lefèvre Amélie Vantaux Kounbobr R Dabiré Karine Mouline Anna Cohuet Non-genetic determinants of mosquito competence for malaria parasites.
description	Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., vector competence. Although the role of environment has long been recognized, much work has focused on host and parasite genetic effects. However, the last few years have seen a surge of studies revealing a great diversity of ways in which non-genetic factors can interfere with mosquito-Plasmodium interactions. Here, we review the current evidence for such environmentally mediated effects, including ambient temperature, mosquito diet, microbial gut flora, and infection history, and we identify additional factors previously overlooked in mosquito-Plasmodium interactions. We also discuss epidemiological implications, and the evolutionary consequences for vector immunity and parasite transmission strategies. Finally, we propose directions for further research and argue that an improved knowledge of non-genetic influences on mosquito-Plasmodium interactions could aid in implementing conventional malaria control measures and contribute to the design of novel strategies.
format	article
author	Thierry Lefèvre Amélie Vantaux Kounbobr R Dabiré Karine Mouline Anna Cohuet
author_facet	Thierry Lefèvre Amélie Vantaux Kounbobr R Dabiré Karine Mouline Anna Cohuet
author_sort	Thierry Lefèvre
title	Non-genetic determinants of mosquito competence for malaria parasites.
title_short	Non-genetic determinants of mosquito competence for malaria parasites.
title_full	Non-genetic determinants of mosquito competence for malaria parasites.
title_fullStr	Non-genetic determinants of mosquito competence for malaria parasites.
title_full_unstemmed	Non-genetic determinants of mosquito competence for malaria parasites.
title_sort	non-genetic determinants of mosquito competence for malaria parasites.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/235790ed586c44ea92a3254815c7a584
work_keys_str_mv	AT thierrylefevre nongeneticdeterminantsofmosquitocompetenceformalariaparasites AT amelievantaux nongeneticdeterminantsofmosquitocompetenceformalariaparasites AT kounbobrrdabire nongeneticdeterminantsofmosquitocompetenceformalariaparasites AT karinemouline nongeneticdeterminantsofmosquitocompetenceformalariaparasites AT annacohuet nongeneticdeterminantsofmosquitocompetenceformalariaparasites
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Non-genetic determinants of mosquito competence for malaria parasites.

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