The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

Abstract Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not bee...

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Autores principales: Hikarua Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Seishu Nakagawa, Kunio Iizuka, Kohei Sakaki, Tsuyoshi Araki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Sugiko Hanawa, Daniele Magistro, Yuka Kotozaki, Yukako Sasaki, Kelssy H. dos S. Kawata, Ryuta Kawashima
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/235a8a067b734a309824dfa821b109da
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spelling oai:doaj.org-article:235a8a067b734a309824dfa821b109da2021-12-02T16:06:40ZThe associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity10.1038/s41598-020-69438-52045-2322https://doaj.org/article/235a8a067b734a309824dfa821b109da2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69438-5https://doaj.org/toc/2045-2322Abstract Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.Hikarua TakeuchiYasuyuki TakiRui NouchiRyoichi YokoyamaSeishu NakagawaKunio IizukaKohei SakakiTsuyoshi ArakiTakayuki NozawaShigeyuki IkedaSusumu YokotaSugiko HanawaDaniele MagistroYuka KotozakiYukako SasakiKelssy H. dos S. KawataRyuta KawashimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hikarua Takeuchi
Yasuyuki Taki
Rui Nouchi
Ryoichi Yokoyama
Seishu Nakagawa
Kunio Iizuka
Kohei Sakaki
Tsuyoshi Araki
Takayuki Nozawa
Shigeyuki Ikeda
Susumu Yokota
Sugiko Hanawa
Daniele Magistro
Yuka Kotozaki
Yukako Sasaki
Kelssy H. dos S. Kawata
Ryuta Kawashima
The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
description Abstract Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.
format article
author Hikarua Takeuchi
Yasuyuki Taki
Rui Nouchi
Ryoichi Yokoyama
Seishu Nakagawa
Kunio Iizuka
Kohei Sakaki
Tsuyoshi Araki
Takayuki Nozawa
Shigeyuki Ikeda
Susumu Yokota
Sugiko Hanawa
Daniele Magistro
Yuka Kotozaki
Yukako Sasaki
Kelssy H. dos S. Kawata
Ryuta Kawashima
author_facet Hikarua Takeuchi
Yasuyuki Taki
Rui Nouchi
Ryoichi Yokoyama
Seishu Nakagawa
Kunio Iizuka
Kohei Sakaki
Tsuyoshi Araki
Takayuki Nozawa
Shigeyuki Ikeda
Susumu Yokota
Sugiko Hanawa
Daniele Magistro
Yuka Kotozaki
Yukako Sasaki
Kelssy H. dos S. Kawata
Ryuta Kawashima
author_sort Hikarua Takeuchi
title The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_short The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_full The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_fullStr The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_full_unstemmed The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
title_sort associations of bmi with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/235a8a067b734a309824dfa821b109da
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