META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09

Interleukin-6 (IL-6) is a potent proinflammatory cytokine, which level is increased in the peripheral blood in many infectious diseases, including the flu A(H1N1)pdm09, in some cases (when the excess of his development of immune cells), resulting not only to strengthen the immune system, but also to...

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Autores principales:	M. V. Shipilov, A. V. Tutelian
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	blobogramm influenza a(h1n1)pdm09 interleukin-6 meta-analysis severity cytokines Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/235c013dd4b8493cae01723dcd794c8c
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spelling	oai:doaj.org-article:235c013dd4b8493cae01723dcd794c8c2021-11-22T07:09:48ZMETA-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm092220-76192313-739810.15789/2220-7619-2017-1-61-68https://doaj.org/article/235c013dd4b8493cae01723dcd794c8c2017-03-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/480https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Interleukin-6 (IL-6) is a potent proinflammatory cytokine, which level is increased in the peripheral blood in many infectious diseases, including the flu A(H1N1)pdm09, in some cases (when the excess of his development of immune cells), resulting not only to strengthen the immune system, but also to the development of a “cytokine storm” is characterized by multi-organ failure and often followed by death. To reduce errors, increase the statistical power and increase the reliability of the results according to different researchers, as well as on the results of their own research was conducted a meta-analysis (a quantitative systematic review) of IL-6 studies in peripheral blood of patients with influenza A(H1N1) pdm09. Question: to determine with a high level of confidence, whether IL-6, a marker of the severity and prognosis of the disease. Searches were carried out research work on this subject in a variety of electronic databases (Medline, EMBASE, the Cochrane Controlled Trials Register, and others), reviews, theses, magazines, conference proceedings, and others. In the process of carrying out a meta-analysis of 5 scientific papers were selected that meet the criteria for inclusion/noninclusion in the study (characteristic of scientific papers, diagnostic criteria, age of patients, comparable groups of patients, the presence of self-control, research methodology, statistical criterion and the total number of independent stu dies). Selected studies have shown sufficient uniformity (homogeneity) comparison groups. The results of the meta-analysis are presented in tables, charts and blobogramme, meta-analysis of 5 scientific papers showed that in moderate and severe influenza A(H1N1)pdm09 noted a significant increase in the concentration of IL-6 in peripheral blood of patients compared with the control a group of individuals (healthy). Severe influenza A(H1N1)pdm09 with a high probability of death is characterized by an even greater increase in IL-6 levels (in comparison with the moderate flow) — 11 pg/ml or more. Thus, the results of a meta-analysis of IL-6 with a high degree of probability is defined as a biomarker of disease severity and prognosis of development. At the same time, a result of meta-analysis of observed quite significant changes of the absolute values of the concentration of IL-6 in peripheral blood, which can be explained by using various test patterns and laboratory equipment, so that necessary to accumulate research experience level IL-6 on one and the same test systems and laboratory equipment.M. V. ShipilovA. V. TutelianSankt-Peterburg : NIIÈM imeni Pasteraarticleblobogramminfluenza a(h1n1)pdm09interleukin-6meta-analysisseveritycytokinesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 7, Iss 1, Pp 61-68 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	blobogramm influenza a(h1n1)pdm09 interleukin-6 meta-analysis severity cytokines Infectious and parasitic diseases RC109-216
spellingShingle	blobogramm influenza a(h1n1)pdm09 interleukin-6 meta-analysis severity cytokines Infectious and parasitic diseases RC109-216 M. V. Shipilov A. V. Tutelian META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09
description	Interleukin-6 (IL-6) is a potent proinflammatory cytokine, which level is increased in the peripheral blood in many infectious diseases, including the flu A(H1N1)pdm09, in some cases (when the excess of his development of immune cells), resulting not only to strengthen the immune system, but also to the development of a “cytokine storm” is characterized by multi-organ failure and often followed by death. To reduce errors, increase the statistical power and increase the reliability of the results according to different researchers, as well as on the results of their own research was conducted a meta-analysis (a quantitative systematic review) of IL-6 studies in peripheral blood of patients with influenza A(H1N1) pdm09. Question: to determine with a high level of confidence, whether IL-6, a marker of the severity and prognosis of the disease. Searches were carried out research work on this subject in a variety of electronic databases (Medline, EMBASE, the Cochrane Controlled Trials Register, and others), reviews, theses, magazines, conference proceedings, and others. In the process of carrying out a meta-analysis of 5 scientific papers were selected that meet the criteria for inclusion/noninclusion in the study (characteristic of scientific papers, diagnostic criteria, age of patients, comparable groups of patients, the presence of self-control, research methodology, statistical criterion and the total number of independent stu dies). Selected studies have shown sufficient uniformity (homogeneity) comparison groups. The results of the meta-analysis are presented in tables, charts and blobogramme, meta-analysis of 5 scientific papers showed that in moderate and severe influenza A(H1N1)pdm09 noted a significant increase in the concentration of IL-6 in peripheral blood of patients compared with the control a group of individuals (healthy). Severe influenza A(H1N1)pdm09 with a high probability of death is characterized by an even greater increase in IL-6 levels (in comparison with the moderate flow) — 11 pg/ml or more. Thus, the results of a meta-analysis of IL-6 with a high degree of probability is defined as a biomarker of disease severity and prognosis of development. At the same time, a result of meta-analysis of observed quite significant changes of the absolute values of the concentration of IL-6 in peripheral blood, which can be explained by using various test patterns and laboratory equipment, so that necessary to accumulate research experience level IL-6 on one and the same test systems and laboratory equipment.
format	article
author	M. V. Shipilov A. V. Tutelian
author_facet	M. V. Shipilov A. V. Tutelian
author_sort	M. V. Shipilov
title	META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09
title_short	META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09
title_full	META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09
title_fullStr	META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09
title_full_unstemmed	META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09
title_sort	meta-analysis of the research of il-6 in peripheral blood of patients with influenza a(h1n1)pdm09
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/235c013dd4b8493cae01723dcd794c8c
work_keys_str_mv	AT mvshipilov metaanalysisoftheresearchofil6inperipheralbloodofpatientswithinfluenzaah1n1pdm09 AT avtutelian metaanalysisoftheresearchofil6inperipheralbloodofpatientswithinfluenzaah1n1pdm09
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META-ANALYSIS OF THE RESEARCH OF IL-6 IN PERIPHERAL BLOOD OF PATIENTS WITH INFLUENZA A(H1N1)pdm09

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