Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs

Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs

The transcription factor Srf is a central regulator of immediate-early and actin cytoskeletal genes. Here the authors show that Srf is activated by repression of β-actin, promoting iPSC reprogramming of neural progenitor cells and hepatoblasts by repressing cell-type specific genes.

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Autores principales: Takashi Ikeda, Takafusa Hikichi, Hisashi Miura, Hirofumi Shibata, Kanae Mitsunaga, Yosuke Yamada, Knut Woltjen, Kei Miyamoto, Ichiro Hiratani, Yasuhiro Yamada, Akitsu Hotta, Takuya Yamamoto, Keisuke Okita, Shinji Masui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/235d41787bb94873a7b3d7b173d5fafc
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spelling oai:doaj.org-article:235d41787bb94873a7b3d7b173d5fafc2021-12-02T17:31:26ZSrf destabilizes cellular identity by suppressing cell-type-specific gene expression programs10.1038/s41467-018-03748-12041-1723https://doaj.org/article/235d41787bb94873a7b3d7b173d5fafc2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03748-1https://doaj.org/toc/2041-1723The transcription factor Srf is a central regulator of immediate-early and actin cytoskeletal genes. Here the authors show that Srf is activated by repression of β-actin, promoting iPSC reprogramming of neural progenitor cells and hepatoblasts by repressing cell-type specific genes.Takashi IkedaTakafusa HikichiHisashi MiuraHirofumi ShibataKanae MitsunagaYosuke YamadaKnut WoltjenKei MiyamotoIchiro HirataniYasuhiro YamadaAkitsu HottaTakuya YamamotoKeisuke OkitaShinji MasuiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Takashi Ikeda
Takafusa Hikichi
Hisashi Miura
Hirofumi Shibata
Kanae Mitsunaga
Yosuke Yamada
Knut Woltjen
Kei Miyamoto
Ichiro Hiratani
Yasuhiro Yamada
Akitsu Hotta
Takuya Yamamoto
Keisuke Okita
Shinji Masui
Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
description The transcription factor Srf is a central regulator of immediate-early and actin cytoskeletal genes. Here the authors show that Srf is activated by repression of β-actin, promoting iPSC reprogramming of neural progenitor cells and hepatoblasts by repressing cell-type specific genes.
format article
author Takashi Ikeda
Takafusa Hikichi
Hisashi Miura
Hirofumi Shibata
Kanae Mitsunaga
Yosuke Yamada
Knut Woltjen
Kei Miyamoto
Ichiro Hiratani
Yasuhiro Yamada
Akitsu Hotta
Takuya Yamamoto
Keisuke Okita
Shinji Masui
author_facet Takashi Ikeda
Takafusa Hikichi
Hisashi Miura
Hirofumi Shibata
Kanae Mitsunaga
Yosuke Yamada
Knut Woltjen
Kei Miyamoto
Ichiro Hiratani
Yasuhiro Yamada
Akitsu Hotta
Takuya Yamamoto
Keisuke Okita
Shinji Masui
author_sort Takashi Ikeda
title Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
title_short Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
title_full Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
title_fullStr Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
title_full_unstemmed Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
title_sort srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/235d41787bb94873a7b3d7b173d5fafc
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