Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs

Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs

The transcription factor Srf is a central regulator of immediate-early and actin cytoskeletal genes. Here the authors show that Srf is activated by repression of β-actin, promoting iPSC reprogramming of neural progenitor cells and hepatoblasts by repressing cell-type specific genes.

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Bibliographic Details
Main Authors: Takashi Ikeda, Takafusa Hikichi, Hisashi Miura, Hirofumi Shibata, Kanae Mitsunaga, Yosuke Yamada, Knut Woltjen, Kei Miyamoto, Ichiro Hiratani, Yasuhiro Yamada, Akitsu Hotta, Takuya Yamamoto, Keisuke Okita, Shinji Masui
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/235d41787bb94873a7b3d7b173d5fafc
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https://doaj.org/article/235d41787bb94873a7b3d7b173d5fafc

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