Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

ABSTRACT In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previously we discovered bacteriophage-encoded Cas9-spe...

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Bibliographic Details
Main Authors: Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, Erik J. Sontheimer
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
CRISPR
Cas9
type II-C
anti-CRISPR
crRNA
Microbiology
QR1-502
Online Access:https://doaj.org/article/235e55b82aeb4666b874a7f3a5f87dce
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https://doaj.org/article/235e55b82aeb4666b874a7f3a5f87dce

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