Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites

In this study, Co0.5Ni0.5Nd0.02Fe1.98O4 nanoparticles CoNiNd (NPs) were synthesized by combustion method linked with biosynthesis with and without different plant extracts such as Lavender, Ginger, Flax-Seed, Lemon Juice, Tragacanth Gum, and Dates Fruit. Co0.5Ni0.5Nd0.02Fe1.98O4 nanoparticles (NPs)...

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Autores principales:	M.A. Almessiere, F.A. Khan, I.A. Auwal, M. Sertkol, N. Tashkandi, I. Rehan, A. Baykal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Green synthesis Plant extract Spinel ferrite nanomaterials Anti-cancer agent Colon cancer cells Cervical cancer cells Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/235f1ffde70f465386e5574743884b93
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spelling	oai:doaj.org-article:235f1ffde70f465386e5574743884b932021-11-26T04:26:16ZGreen synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites1878-535210.1016/j.arabjc.2021.103564https://doaj.org/article/235f1ffde70f465386e5574743884b932022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005797https://doaj.org/toc/1878-5352In this study, Co0.5Ni0.5Nd0.02Fe1.98O4 nanoparticles CoNiNd (NPs) were synthesized by combustion method linked with biosynthesis with and without different plant extracts such as Lavender, Ginger, Flax-Seed, Lemon Juice, Tragacanth Gum, and Dates Fruit. Co0.5Ni0.5Nd0.02Fe1.98O4 nanoparticles (NPs) with plant extracts (CoNiNd plant extracts) were analyzed by XRD, TEM and SEM methods. The structure of Co-Ni spinel ferrite was confirmed by XRD and the shape and the size of nanoparticles were examined via SEM and TEM and the size was found between 17 and 25 nm. The anti-cancer activity of NPs on cancer cells such as human colorectal carcinoma (HCT-116) and human cervical cells (Hela) were investigated. The cytotoxicity of was examined by MTT assay and followed by measuring the inhibitory concentration (IC50) values after 48 h treatments. The cell viability assay confirmed a decrease in the cancer cell viability post NPs treatments and showed dose-dependent inhibitory action. The treatments of CoNiNd (NPs) and CoNiNd plant extracts via Lavender plant extract showed most profound inhibitory action on both cancer cells than extracts other plant extracts. The IC50 values were for HCT-116 cells were found to be in range of 15.75–42.55 µg/mL and 13.44 to 35.65 µg/mL for HeLa cells. In contrast, the treatment of CoNiNd (NPs) and CoNiNd plant extracts showed inhibitory action but the percentage of inhibition was higher in HEK-293 cells. Our results showed that CoNiNd (NPs) and CoNiNd plant extracts possess potential application in the colon and cervical cancer treatments and we recommend molecular analysis of NPs mediated cancer cell death for future applications.M.A. AlmessiereF.A. KhanI.A. AuwalM. SertkolN. TashkandiI. RehanA. BaykalElsevierarticleGreen synthesisPlant extractSpinel ferrite nanomaterialsAnti-cancer agentColon cancer cellsCervical cancer cellsChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 2, Pp 103564- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Green synthesis Plant extract Spinel ferrite nanomaterials Anti-cancer agent Colon cancer cells Cervical cancer cells Chemistry QD1-999
spellingShingle	Green synthesis Plant extract Spinel ferrite nanomaterials Anti-cancer agent Colon cancer cells Cervical cancer cells Chemistry QD1-999 M.A. Almessiere F.A. Khan I.A. Auwal M. Sertkol N. Tashkandi I. Rehan A. Baykal Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites
description	In this study, Co0.5Ni0.5Nd0.02Fe1.98O4 nanoparticles CoNiNd (NPs) were synthesized by combustion method linked with biosynthesis with and without different plant extracts such as Lavender, Ginger, Flax-Seed, Lemon Juice, Tragacanth Gum, and Dates Fruit. Co0.5Ni0.5Nd0.02Fe1.98O4 nanoparticles (NPs) with plant extracts (CoNiNd plant extracts) were analyzed by XRD, TEM and SEM methods. The structure of Co-Ni spinel ferrite was confirmed by XRD and the shape and the size of nanoparticles were examined via SEM and TEM and the size was found between 17 and 25 nm. The anti-cancer activity of NPs on cancer cells such as human colorectal carcinoma (HCT-116) and human cervical cells (Hela) were investigated. The cytotoxicity of was examined by MTT assay and followed by measuring the inhibitory concentration (IC50) values after 48 h treatments. The cell viability assay confirmed a decrease in the cancer cell viability post NPs treatments and showed dose-dependent inhibitory action. The treatments of CoNiNd (NPs) and CoNiNd plant extracts via Lavender plant extract showed most profound inhibitory action on both cancer cells than extracts other plant extracts. The IC50 values were for HCT-116 cells were found to be in range of 15.75–42.55 µg/mL and 13.44 to 35.65 µg/mL for HeLa cells. In contrast, the treatment of CoNiNd (NPs) and CoNiNd plant extracts showed inhibitory action but the percentage of inhibition was higher in HEK-293 cells. Our results showed that CoNiNd (NPs) and CoNiNd plant extracts possess potential application in the colon and cervical cancer treatments and we recommend molecular analysis of NPs mediated cancer cell death for future applications.
format	article
author	M.A. Almessiere F.A. Khan I.A. Auwal M. Sertkol N. Tashkandi I. Rehan A. Baykal
author_facet	M.A. Almessiere F.A. Khan I.A. Auwal M. Sertkol N. Tashkandi I. Rehan A. Baykal
author_sort	M.A. Almessiere
title	Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites
title_short	Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites
title_full	Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites
title_fullStr	Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites
title_full_unstemmed	Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites
title_sort	green synthesis, characterization and anti-cancer capability of co0.5ni0.5nd0.02fe1.98o4 nanocomposites
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/235f1ffde70f465386e5574743884b93
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_version_	1718409888869122048

Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites

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