CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy

Targeting the immune-stimulatory receptor 4-1BB has only yielded modest benefit in cancer treatment. In this study, the authors show that CD73 expression on effector T cells sustained by TGF-β drives tumor resistance to anti-4-1BB therapy and therefore TGF- β blockade can be used to overcome such re...

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Autores principales:	Siqi Chen, Jie Fan, Minghui Zhang, Lei Qin, Donye Dominguez, Alan Long, Gaoxiang Wang, Renqiang Ma, Huabin Li, Yi Zhang, Deyu Fang, Jeffrey Sosman, Bin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/235ff9bd6b974909b1dbb2d39fa66731
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spelling	oai:doaj.org-article:235ff9bd6b974909b1dbb2d39fa667312021-12-02T15:35:38ZCD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy10.1038/s41467-018-08123-82041-1723https://doaj.org/article/235ff9bd6b974909b1dbb2d39fa667312019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08123-8https://doaj.org/toc/2041-1723Targeting the immune-stimulatory receptor 4-1BB has only yielded modest benefit in cancer treatment. In this study, the authors show that CD73 expression on effector T cells sustained by TGF-β drives tumor resistance to anti-4-1BB therapy and therefore TGF- β blockade can be used to overcome such resistance.Siqi ChenJie FanMinghui ZhangLei QinDonye DominguezAlan LongGaoxiang WangRenqiang MaHuabin LiYi ZhangDeyu FangJeffrey SosmanBin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siqi Chen Jie Fan Minghui Zhang Lei Qin Donye Dominguez Alan Long Gaoxiang Wang Renqiang Ma Huabin Li Yi Zhang Deyu Fang Jeffrey Sosman Bin Zhang CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
description	Targeting the immune-stimulatory receptor 4-1BB has only yielded modest benefit in cancer treatment. In this study, the authors show that CD73 expression on effector T cells sustained by TGF-β drives tumor resistance to anti-4-1BB therapy and therefore TGF- β blockade can be used to overcome such resistance.
format	article
author	Siqi Chen Jie Fan Minghui Zhang Lei Qin Donye Dominguez Alan Long Gaoxiang Wang Renqiang Ma Huabin Li Yi Zhang Deyu Fang Jeffrey Sosman Bin Zhang
author_facet	Siqi Chen Jie Fan Minghui Zhang Lei Qin Donye Dominguez Alan Long Gaoxiang Wang Renqiang Ma Huabin Li Yi Zhang Deyu Fang Jeffrey Sosman Bin Zhang
author_sort	Siqi Chen
title	CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
title_short	CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
title_full	CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
title_fullStr	CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
title_full_unstemmed	CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
title_sort	cd73 expression on effector t cells sustained by tgf-β facilitates tumor resistance to anti-4-1bb/cd137 therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/235ff9bd6b974909b1dbb2d39fa66731
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CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy

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