Reduced SOD2 expression does not influence prion disease course or pathology in mice.

Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the hallmark spongiform change seen in the brain, these diseases manifest increased oxidative damage early in disease and changes in antioxidant e...

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Autores principales: Simote T Foliaki, Brent Race, Katie Williams, Chase Baune, Bradley R Groveman, Cathryn L Haigh
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Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/23606fe40de04f528270e8cb9d2e7f10
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spelling oai:doaj.org-article:23606fe40de04f528270e8cb9d2e7f102021-12-02T20:04:18ZReduced SOD2 expression does not influence prion disease course or pathology in mice.1932-620310.1371/journal.pone.0259597https://doaj.org/article/23606fe40de04f528270e8cb9d2e7f102021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259597https://doaj.org/toc/1932-6203Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the hallmark spongiform change seen in the brain, these diseases manifest increased oxidative damage early in disease and changes in antioxidant enzymes in terminal brain tissue. Superoxide dismutase 2 (SOD2) is an antioxidant enzyme that is critical for life. SOD2 knock-out mice can only be kept alive for several weeks post-birth and only with antioxidant therapy. However, this results in the development of a spongiform encephalopathy. Consequently, we hypothesized that reduced levels of SOD2 may accelerate prion disease progression and play a critical role in the formation of spongiform change. Using SOD2 heterozygous knock-out and litter mate wild-type controls, we examined neuronal long-term potentiation, disease duration, pathology, and degree of spongiform change in mice infected with three strains of mouse adapted scrapie. No influence of the reduced SOD2 expression was observed in any parameter measured for any strain. We conclude that changes relating to SOD2 during prion disease are most likely secondary to the disease processes causing toxicity and do not influence the development of spongiform pathology.Simote T FoliakiBrent RaceKatie WilliamsChase BauneBradley R GrovemanCathryn L HaighPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259597 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Simote T Foliaki
Brent Race
Katie Williams
Chase Baune
Bradley R Groveman
Cathryn L Haigh
Reduced SOD2 expression does not influence prion disease course or pathology in mice.
description Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the hallmark spongiform change seen in the brain, these diseases manifest increased oxidative damage early in disease and changes in antioxidant enzymes in terminal brain tissue. Superoxide dismutase 2 (SOD2) is an antioxidant enzyme that is critical for life. SOD2 knock-out mice can only be kept alive for several weeks post-birth and only with antioxidant therapy. However, this results in the development of a spongiform encephalopathy. Consequently, we hypothesized that reduced levels of SOD2 may accelerate prion disease progression and play a critical role in the formation of spongiform change. Using SOD2 heterozygous knock-out and litter mate wild-type controls, we examined neuronal long-term potentiation, disease duration, pathology, and degree of spongiform change in mice infected with three strains of mouse adapted scrapie. No influence of the reduced SOD2 expression was observed in any parameter measured for any strain. We conclude that changes relating to SOD2 during prion disease are most likely secondary to the disease processes causing toxicity and do not influence the development of spongiform pathology.
format article
author Simote T Foliaki
Brent Race
Katie Williams
Chase Baune
Bradley R Groveman
Cathryn L Haigh
author_facet Simote T Foliaki
Brent Race
Katie Williams
Chase Baune
Bradley R Groveman
Cathryn L Haigh
author_sort Simote T Foliaki
title Reduced SOD2 expression does not influence prion disease course or pathology in mice.
title_short Reduced SOD2 expression does not influence prion disease course or pathology in mice.
title_full Reduced SOD2 expression does not influence prion disease course or pathology in mice.
title_fullStr Reduced SOD2 expression does not influence prion disease course or pathology in mice.
title_full_unstemmed Reduced SOD2 expression does not influence prion disease course or pathology in mice.
title_sort reduced sod2 expression does not influence prion disease course or pathology in mice.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/23606fe40de04f528270e8cb9d2e7f10
work_keys_str_mv AT simotetfoliaki reducedsod2expressiondoesnotinfluencepriondiseasecourseorpathologyinmice
AT brentrace reducedsod2expressiondoesnotinfluencepriondiseasecourseorpathologyinmice
AT katiewilliams reducedsod2expressiondoesnotinfluencepriondiseasecourseorpathologyinmice
AT chasebaune reducedsod2expressiondoesnotinfluencepriondiseasecourseorpathologyinmice
AT bradleyrgroveman reducedsod2expressiondoesnotinfluencepriondiseasecourseorpathologyinmice
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