Analysis of a novel X-ray lens for converging beam radiotherapy

Abstract We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a...

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Autores principales:	Dirk A. Bartkoski, Aharon Bar-David, Michael Kleckner, Dragan Mirkovic, Ramesh Tailor, Jamshid Moradi-Kurdestany, Shirly Borukhin, Ze’ev Harel, Zeev Burshtein, Asaf Zuck, Mohammad Salehpour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23608c141f9d482ea1dac29a4da67a24
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spelling	oai:doaj.org-article:23608c141f9d482ea1dac29a4da67a242021-12-02T17:18:21ZAnalysis of a novel X-ray lens for converging beam radiotherapy10.1038/s41598-021-98888-82045-2322https://doaj.org/article/23608c141f9d482ea1dac29a4da67a242021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98888-8https://doaj.org/toc/2045-2322Abstract We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy.Dirk A. BartkoskiAharon Bar-DavidMichael KlecknerDragan MirkovicRamesh TailorJamshid Moradi-KurdestanyShirly BorukhinZe’ev HarelZeev BurshteinAsaf ZuckMohammad SalehpourNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dirk A. Bartkoski Aharon Bar-David Michael Kleckner Dragan Mirkovic Ramesh Tailor Jamshid Moradi-Kurdestany Shirly Borukhin Ze’ev Harel Zeev Burshtein Asaf Zuck Mohammad Salehpour Analysis of a novel X-ray lens for converging beam radiotherapy
description	Abstract We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy.
format	article
author	Dirk A. Bartkoski Aharon Bar-David Michael Kleckner Dragan Mirkovic Ramesh Tailor Jamshid Moradi-Kurdestany Shirly Borukhin Ze’ev Harel Zeev Burshtein Asaf Zuck Mohammad Salehpour
author_facet	Dirk A. Bartkoski Aharon Bar-David Michael Kleckner Dragan Mirkovic Ramesh Tailor Jamshid Moradi-Kurdestany Shirly Borukhin Ze’ev Harel Zeev Burshtein Asaf Zuck Mohammad Salehpour
author_sort	Dirk A. Bartkoski
title	Analysis of a novel X-ray lens for converging beam radiotherapy
title_short	Analysis of a novel X-ray lens for converging beam radiotherapy
title_full	Analysis of a novel X-ray lens for converging beam radiotherapy
title_fullStr	Analysis of a novel X-ray lens for converging beam radiotherapy
title_full_unstemmed	Analysis of a novel X-ray lens for converging beam radiotherapy
title_sort	analysis of a novel x-ray lens for converging beam radiotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23608c141f9d482ea1dac29a4da67a24
work_keys_str_mv	AT dirkabartkoski analysisofanovelxraylensforconvergingbeamradiotherapy AT aharonbardavid analysisofanovelxraylensforconvergingbeamradiotherapy AT michaelkleckner analysisofanovelxraylensforconvergingbeamradiotherapy AT draganmirkovic analysisofanovelxraylensforconvergingbeamradiotherapy AT rameshtailor analysisofanovelxraylensforconvergingbeamradiotherapy AT jamshidmoradikurdestany analysisofanovelxraylensforconvergingbeamradiotherapy AT shirlyborukhin analysisofanovelxraylensforconvergingbeamradiotherapy AT zeevharel analysisofanovelxraylensforconvergingbeamradiotherapy AT zeevburshtein analysisofanovelxraylensforconvergingbeamradiotherapy AT asafzuck analysisofanovelxraylensforconvergingbeamradiotherapy AT mohammadsalehpour analysisofanovelxraylensforconvergingbeamradiotherapy
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Analysis of a novel X-ray lens for converging beam radiotherapy

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