The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat

Background and Objective: There is complex interaction between corticosteroids and opioid system receptors. This study was designed to investigate the interaction between the effect of Dexamethasone (DEX) and morphine in opioid physical dependence in rat. Methods: In present study, 63 male wistar ra...

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Autores principales:	TP Kalantari Pour, N Atapour
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2004
Materias:	morphine withdrawal dexamethasone (dex) glucocorticoid antagonist (ru 38486) spironolatone Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2363f82d41d34f539787e546981a5135
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spelling	oai:doaj.org-article:2363f82d41d34f539787e546981a51352021-11-10T09:15:56ZThe role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat1561-41072251-7170https://doaj.org/article/2363f82d41d34f539787e546981a51352004-01-01T00:00:00Zhttp://jbums.org/article-1-2733-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: There is complex interaction between corticosteroids and opioid system receptors. This study was designed to investigate the interaction between the effect of Dexamethasone (DEX) and morphine in opioid physical dependence in rat. Methods: In present study, 63 male wistar rats weighing 200-250 gr were selected. Rats were made dependent by injecting cumulative doses of morphine (40-120 mg/kg/sc) twice daily for six days. For evaluation of DEX effects and involved receptors, DEX was injected 1hr prior of morphine with or without one of steroid receptors antagonists (RU 38486, selective glucocorticoid receptor antagonist and spironolactone, selective mineralocorticoid receptor antagonist). The withdrawal syndrome precipitated by injection of naloxone (2 mg/kg) was induced as an indicator of morphine dependency. These behavioral parameters (Jumping, wet-dog shake, weight loss and diarrhea) were surveyed. Additionally, plasma corticosterone (PCs) had been used as another indicator of morphine dependency. Findings: This study showed that DEX could decrease the withdrawal signs (17% weight loss 51% jumping, 28% wet-dog shake and 44% diarrhea [P<0.05]) after naloxone. Pretreatment with spironolactone and RU38486 induced variations in morphine withdrawal signs. Also, co-administration of these antagonists with DEX and morphine induced modifications in withdrawal signs. Inhibition of steroid receptors could increase of PCs and co-administration of these antagonists with DEX and morphine significantly reduced PCs compared with control groups (P<0.001). Conclusion: As the results, it could be suggested that pretreatment with DEX can decrease the level of morphine physical dependency.TP Kalantari PourN AtapourBabol University of Medical Sciencesarticlemorphine withdrawaldexamethasone (dex)glucocorticoid antagonist (ru 38486)spironolatoneMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 6, Iss 1, Pp 14-20 (2004)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	morphine withdrawal dexamethasone (dex) glucocorticoid antagonist (ru 38486) spironolatone Medicine R Medicine (General) R5-920
spellingShingle	morphine withdrawal dexamethasone (dex) glucocorticoid antagonist (ru 38486) spironolatone Medicine R Medicine (General) R5-920 TP Kalantari Pour N Atapour The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat
description	Background and Objective: There is complex interaction between corticosteroids and opioid system receptors. This study was designed to investigate the interaction between the effect of Dexamethasone (DEX) and morphine in opioid physical dependence in rat. Methods: In present study, 63 male wistar rats weighing 200-250 gr were selected. Rats were made dependent by injecting cumulative doses of morphine (40-120 mg/kg/sc) twice daily for six days. For evaluation of DEX effects and involved receptors, DEX was injected 1hr prior of morphine with or without one of steroid receptors antagonists (RU 38486, selective glucocorticoid receptor antagonist and spironolactone, selective mineralocorticoid receptor antagonist). The withdrawal syndrome precipitated by injection of naloxone (2 mg/kg) was induced as an indicator of morphine dependency. These behavioral parameters (Jumping, wet-dog shake, weight loss and diarrhea) were surveyed. Additionally, plasma corticosterone (PCs) had been used as another indicator of morphine dependency. Findings: This study showed that DEX could decrease the withdrawal signs (17% weight loss 51% jumping, 28% wet-dog shake and 44% diarrhea [P<0.05]) after naloxone. Pretreatment with spironolactone and RU38486 induced variations in morphine withdrawal signs. Also, co-administration of these antagonists with DEX and morphine induced modifications in withdrawal signs. Inhibition of steroid receptors could increase of PCs and co-administration of these antagonists with DEX and morphine significantly reduced PCs compared with control groups (P<0.001). Conclusion: As the results, it could be suggested that pretreatment with DEX can decrease the level of morphine physical dependency.
format	article
author	TP Kalantari Pour N Atapour
author_facet	TP Kalantari Pour N Atapour
author_sort	TP Kalantari Pour
title	The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat
title_short	The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat
title_full	The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat
title_fullStr	The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat
title_full_unstemmed	The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat
title_sort	role of pretreatment with dexamethasone on inhibition of acute morphine physical dependence in rat
publisher	Babol University of Medical Sciences
publishDate	2004
url	https://doaj.org/article/2363f82d41d34f539787e546981a5135
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The role of pretreatment with Dexamethasone on inhibition of acute Morphine physical dependence in rat

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