Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells

Abstract The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VL...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Nicholas J. Maness, Marie-Audrey I. Kautzmann, Aram Asatryan, William C. Gordon, Khanh V. Do, Bokkyoo Jun, Pranab K. Mukherjee, Nicos A. Petasis, Nicolas G. Bazan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23649788b0954184a9a2a7b9024ba830
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:23649788b0954184a9a2a7b9024ba830
record_format	dspace
spelling	oai:doaj.org-article:23649788b0954184a9a2a7b9024ba8302021-12-02T15:03:07ZElovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells10.1038/s41598-021-91794-z2045-2322https://doaj.org/article/23649788b0954184a9a2a7b9024ba8302021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91794-zhttps://doaj.org/toc/2045-2322Abstract The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA, n-3) activate ELV biosynthesis in lung cells. Both ELVs and their precursors reduce the binding to RBD. ELVs downregulate angiotensin-converting enzyme 2 (ACE2) and enhance the expression of a set of protective proteins hindering cell surface virus binding and upregulating defensive proteins against lung damage. In addition, ELVs and their precursors decreased the signal of spike (S) protein found in SARS-CoV-2 infected cells, suggesting that the lipids curb viral infection. These findings open avenues for potential preventive and disease-modifiable therapeutic approaches for COVID-19.Jorgelina M. CalandriaSurjyadipta BhattacharjeeNicholas J. ManessMarie-Audrey I. KautzmannAram AsatryanWilliam C. GordonKhanh V. DoBokkyoo JunPranab K. MukherjeeNicos A. PetasisNicolas G. BazanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorgelina M. Calandria Surjyadipta Bhattacharjee Nicholas J. Maness Marie-Audrey I. Kautzmann Aram Asatryan William C. Gordon Khanh V. Do Bokkyoo Jun Pranab K. Mukherjee Nicos A. Petasis Nicolas G. Bazan Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
description	Abstract The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA, n-3) activate ELV biosynthesis in lung cells. Both ELVs and their precursors reduce the binding to RBD. ELVs downregulate angiotensin-converting enzyme 2 (ACE2) and enhance the expression of a set of protective proteins hindering cell surface virus binding and upregulating defensive proteins against lung damage. In addition, ELVs and their precursors decreased the signal of spike (S) protein found in SARS-CoV-2 infected cells, suggesting that the lipids curb viral infection. These findings open avenues for potential preventive and disease-modifiable therapeutic approaches for COVID-19.
format	article
author	Jorgelina M. Calandria Surjyadipta Bhattacharjee Nicholas J. Maness Marie-Audrey I. Kautzmann Aram Asatryan William C. Gordon Khanh V. Do Bokkyoo Jun Pranab K. Mukherjee Nicos A. Petasis Nicolas G. Bazan
author_facet	Jorgelina M. Calandria Surjyadipta Bhattacharjee Nicholas J. Maness Marie-Audrey I. Kautzmann Aram Asatryan William C. Gordon Khanh V. Do Bokkyoo Jun Pranab K. Mukherjee Nicos A. Petasis Nicolas G. Bazan
author_sort	Jorgelina M. Calandria
title	Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
title_short	Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
title_full	Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
title_fullStr	Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
title_full_unstemmed	Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
title_sort	elovanoids downregulate sars-cov-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23649788b0954184a9a2a7b9024ba830
work_keys_str_mv	AT jorgelinamcalandria elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT surjyadiptabhattacharjee elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT nicholasjmaness elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT marieaudreyikautzmann elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT aramasatryan elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT williamcgordon elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT khanhvdo elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT bokkyoojun elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT pranabkmukherjee elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT nicosapetasis elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells AT nicolasgbazan elovanoidsdownregulatesarscov2cellentrycanonicalmediatorsandenhanceprotectivesignalinginhumanalveolarcells
_version_	1718389064511520768

Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells

Ejemplares similares