Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger

Cardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recovery in CVD patients. Nevertheless, elusive and multifactorial p...

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Autores principales:	Anshul S. Jadli, Ananya Parasor, Karina P. Gomes, Ruchita Shandilya, Vaibhav B. Patel
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	extracellular vesicles exosomes cardiovascular disease heart failure atherosclerosis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/236635b768df498189eb94d788c86f61
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spelling	oai:doaj.org-article:236635b768df498189eb94d788c86f612021-11-12T05:08:22ZExosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger2297-055X10.3389/fcvm.2021.767488https://doaj.org/article/236635b768df498189eb94d788c86f612021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.767488/fullhttps://doaj.org/toc/2297-055XCardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recovery in CVD patients. Nevertheless, elusive and multifactorial pathophysiological mechanisms of CVD development perplexed researchers in identifying efficacious therapeutic interventions. Search for novel and effective strategies for diagnosis, prevention, and intervention for CVD has shifted research focus on extracellular vesicles (EVs) in recent years. By transporting molecular cargo from donor to recipient cells, EVs modulate gene expression and influence the phenotype of recipient cells, thus EVs prove to be an imperative component of intercellular signaling. Elucidation of the role of EVs in intercellular communications under physiological conditions implied the enormous potential of EVs in monitoring and treatment of CVD. The EVs secreted from the myriad of cells in the cardiovascular system such as cardiomyocytes, cardiac fibroblasts, cardiac progenitor cells, endothelial cells, inflammatory cells may facilitate the communication in physiological and pathological conditions. Understanding EVs-mediated cellular communication may delineate the mechanism of origin and progression of cardiovascular diseases. The current review summarizes exosome-mediated paracrine signaling leading to cardiovascular disease. The mechanistic role of exosomes in cardiovascular disease will provide novel avenues in designing diagnosis and therapeutic interventions.Anshul S. JadliAnshul S. JadliAnanya ParasorAnanya ParasorKarina P. GomesKarina P. GomesRuchita ShandilyaRuchita ShandilyaVaibhav B. PatelVaibhav B. PatelFrontiers Media S.A.articleextracellular vesiclesexosomescardiovascular diseaseheart failureatherosclerosisDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular vesicles exosomes cardiovascular disease heart failure atherosclerosis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	extracellular vesicles exosomes cardiovascular disease heart failure atherosclerosis Diseases of the circulatory (Cardiovascular) system RC666-701 Anshul S. Jadli Anshul S. Jadli Ananya Parasor Ananya Parasor Karina P. Gomes Karina P. Gomes Ruchita Shandilya Ruchita Shandilya Vaibhav B. Patel Vaibhav B. Patel Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
description	Cardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recovery in CVD patients. Nevertheless, elusive and multifactorial pathophysiological mechanisms of CVD development perplexed researchers in identifying efficacious therapeutic interventions. Search for novel and effective strategies for diagnosis, prevention, and intervention for CVD has shifted research focus on extracellular vesicles (EVs) in recent years. By transporting molecular cargo from donor to recipient cells, EVs modulate gene expression and influence the phenotype of recipient cells, thus EVs prove to be an imperative component of intercellular signaling. Elucidation of the role of EVs in intercellular communications under physiological conditions implied the enormous potential of EVs in monitoring and treatment of CVD. The EVs secreted from the myriad of cells in the cardiovascular system such as cardiomyocytes, cardiac fibroblasts, cardiac progenitor cells, endothelial cells, inflammatory cells may facilitate the communication in physiological and pathological conditions. Understanding EVs-mediated cellular communication may delineate the mechanism of origin and progression of cardiovascular diseases. The current review summarizes exosome-mediated paracrine signaling leading to cardiovascular disease. The mechanistic role of exosomes in cardiovascular disease will provide novel avenues in designing diagnosis and therapeutic interventions.
format	article
author	Anshul S. Jadli Anshul S. Jadli Ananya Parasor Ananya Parasor Karina P. Gomes Karina P. Gomes Ruchita Shandilya Ruchita Shandilya Vaibhav B. Patel Vaibhav B. Patel
author_facet	Anshul S. Jadli Anshul S. Jadli Ananya Parasor Ananya Parasor Karina P. Gomes Karina P. Gomes Ruchita Shandilya Ruchita Shandilya Vaibhav B. Patel Vaibhav B. Patel
author_sort	Anshul S. Jadli
title	Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
title_short	Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
title_full	Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
title_fullStr	Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
title_full_unstemmed	Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
title_sort	exosomes in cardiovascular diseases: pathological potential of nano-messenger
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/236635b768df498189eb94d788c86f61
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Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger

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